| Gene Symbol | GABRB3 |
|---|---|
| Entrez Gene | 2562 |
| Alt Symbol | ECA5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | gamma-aminobutyric acid (GABA) A receptor, beta 3 |
| Other Description | GABA-alpha receptor beta-2 subunit|GABAA receptor beta-3 subunit|gamma-aminobutyric acid A receptor beta 3|gamma-aminobutyric acid receptor subunit beta-3 |
| Swissprots | B7Z2W1 F5H3D2 B7Z825 Q96FM5 P28472 Q14352 H7BYV8 |
| Accessions | AAA52507 AAA52508 EAW57653 EAW57654 EAW57655 P28472 AK056018 AK095011 AK295167 BAH11997 AK302822 BAH13811 AK315311 BAG37715 AL120032 AW294342 BC010641 AAH10641 BC038837 BE220174 BE783170 CB162957 CD013894 CD652458 CR747353 DA138788 DB479831 DN994054 DQ891086 ABM82012 EU176555 ABW03356 KJ534842 AHW56482 M82919 AAA52511 XM_011521428 XP_011519730 NM_000814 NP_000805 NM_001191320 NP_001178249 NM_001191321 NP_001178250 NM_001278631 NP_001265560 NM_021912 NP_068712 NR_103801 |
| Function | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:18514161, ECO:0000269|PubMed:22243422, ECO:0000269|PubMed:22303015, ECO:0000269|PubMed:24909990}. |
| Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Top Pathways | GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction |