PINK1

Gene Symbol PINK1
Entrez Gene 65018
Alt Symbol BRPK, PARK6
Species Human
Gene Type protein-coding
Description PTEN induced putative kinase 1
Other Description PTEN-induced putative kinase protein 1|protein kinase BRPK|serine/threonine-protein kinase PINK1, mitochondrial
Swissprots Q8N6T9 Q9BXM7 Q96DE4 Q8NBU3
Accessions CBX51399 EAW94934 EAW94935 Q9BXM7 AB053323 BAB55647 AF316873 AAK28062 AK075225 BAC11484 AK130746 BC009534 AAH09534 BC028215 AAH28215 DQ891033 ABM81959 DQ893330 ABM84256 DQ894212 ABM85138 DQ896646 ABM87645 NM_032409 NP_115785
Function Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). {ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291}.
Subcellular Location Mitochondrion outer membrane; Single-pass membrane protein {ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:18687899, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23933751}. Cytoplasm, cytosol {ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600}. Note=Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol. {ECO:0000269|PubMed:19229105}.
Tissue Specificity Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. {ECO:0000269|PubMed:11494141}.

PINK1 CRISPR/Cas9 KO Plasmid (h) - sc-400739 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PINK1 HDR Plasmid (h) - sc-400739-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PINK1 Double Nickase Plasmid (h) - sc-400739-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PINK1 Double Nickase Plasmid (h2) - sc-400739-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PINK1 CRISPR Activation Plasmid (h) - sc-400739-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PINK1 CRISPR Activation Plasmid (h2) - sc-400739-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PINK1 Lentiviral Activation Particles (h) - sc-400739-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PINK1 Lentiviral Activation Particles (h2) - sc-400739-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PINK1 siRNA (h) - sc-44598 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PINK1 shRNA Plasmid (h) - sc-44598-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PINK1 shRNA (h) Lentiviral Particles - sc-44598-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PINK1 RNAi - H00065018-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
PINK1 RNAi [H00065018-R03] - Homo sapiens PTEN induced putative kinase 1 (PINK1), mRNA.

MISSION® esiRNA - EHU057101 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK1690 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1689 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1688 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1288 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1288 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06749 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06749

PINK1 siRNA (Human) - CRJ2166 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PINK1 (NM_032409.2) - SHH375944 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PINK1(NM_032409.2) - SHR115368 from Creative biogene

Category siRNA
Species Reactivities Human

Human PINK1 siRNA - orb272667 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PINK1 shRNA Plasmid (Human) - CHJ2166 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PINK1 miRNA 3'UTR clone - MiUTR1H-07920 from Creative biogene

Species Reactivities Human
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