EFNA4

Gene Symbol EFNA4
Entrez Gene 1945
Alt Symbol EFL4, EPLG4, LERK4
Species Human
Gene Type protein-coding
Description ephrin-A4
Other Description LERK-4|eph-related receptor tyrosine kinase ligand 4|ligand of eph-related kinase 4
Swissprots C9JHJ8 Q6FI57 O95457 Q5SR71 G3XAK2 P52798
Accessions CAC48189 EAW53138 EAW53139 EAW53140 P52798 AI459151 AI625552 AJ006352 CAA06992 AJ006353 CAA06993 BC042610 BC107483 AAI07484 BE780161 BM740848 BM747625 BQ940212 CD671399 CR533569 CAG38600 U14188 AAC50079 NM_005227 NP_005218 NM_182689 NP_872631 NM_182690 NP_872632
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
Subcellular Location Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.
Tissue Specificity Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
Top Pathways Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway