| Gene Symbol |
EFNA4
|
| Entrez Gene |
1945
|
| Alt Symbol |
EFL4, EPLG4, LERK4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ephrin-A4
|
| Other Description |
LERK-4|eph-related receptor tyrosine kinase ligand 4|ligand of eph-related kinase 4
|
| Swissprots |
C9JHJ8 Q6FI57 O95457 Q5SR71 G3XAK2 P52798
|
| Accessions |
CAC48189 EAW53138 EAW53139 EAW53140 P52798 AI459151 AI625552 AJ006352 CAA06992 AJ006353 CAA06993 BC042610 BC107483 AAI07484 BE780161 BM740848 BM747625 BQ940212 CD671399 CR533569 CAG38600 U14188 AAC50079 NM_005227 NP_005218 NM_182689 NP_872631 NM_182690 NP_872632
|
| Function |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
|
| Subcellular Location |
Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.
|
| Tissue Specificity |
Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
|
| Top Pathways |
Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway
|
![Western Blot: Ephrin A4 Overexpression Lysate (Adult Normal) [NBP2-04833] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Ephrin A4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5034_Ephrin%2520A4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04833-img0001.jpg)
![Western Blot: Ephrin A4 Overexpression Lysate (Adult Normal) [NBP2-10484] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Ephrin A4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2207_Ephrin%2520A4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10484-img0001.jpg)