CALR

Gene Symbol CALR
Entrez Gene 811
Alt Symbol CRT, HEL-S-99n, RO, SSA, cC1qR
Species Human
Gene Type protein-coding
Description calreticulin
Other Description CRP55|ERp60|HACBP|Sicca syndrome antigen A (autoantigen Ro; calreticulin)|calregulin|endoplasmic reticulum resident protein 60|epididymis secretory sperm binding protein Li 99n|grp60
Swissprots Q9UDG2 Q6IAT4 P27797
Accessions AAB51176 CAK18761 CCD35250 CRH09108 EAW84330 EAW84331 EAW84332 P27797 AB451408 BAG70222 AF087986 AK130190 AK223060 BAD96780 AK295230 BAG58223 AK304492 BAG65301 AY047586 AAL13126 BC002500 AAH02500 BC007911 AAH07911 BC020493 AAH20493 BC107102 BT007448 AAP36116 CR457070 CAG33351 FJ224311 ACI46003 M32294 AAA36582 M84739 AAA51916 NM_004343 NP_004334
Function Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). {ECO:0000250}.
Subcellular Location Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen {ECO:0000250}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.
Top Pathways Chagas disease (American trypanosomiasis), Phagosome, Protein processing in endoplasmic reticulum, HTLV-I infection, Antigen processing and presentation

Calreticulin (D3E6) XP ® Rabbit mAb - 12238 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3E6
Western blot analysis of extracts from SH-SY5Y and KNRK cells using Calreticulin (D3E6) XP ® Rabbit mAb.

Calreticulin Antibody - 2891 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and C6 cells using Calreticulin Antibody.

Calregulin (H-10) - sc-166839 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Calregulin (H-10): sc-166839. Western blot analysis of Calregulin expression in HeLa (A) and SK-MEL-28 (B) whole cell lysates.

Calregulin (F-4) - sc-373863 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Calregulin (F-4): sc-373863. Western blot analysis of Calregulin expression in HeLa (A) and MCF7 (B) whole cell lysates.

Calregulin (C-17) - sc-6467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Calregulin (C-17): sc-6467. Western blot analysis of Calregulin expression in HeLa (A), SK-MEL-28 (B) and NIH/3T3 (C) whole cell lysates.

Calregulin (A-9) - sc-166837 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Calregulin (A-9): sc-166837. Western blot analysis of Calregulin expression in HeLa (A) and MCF7 (B) whole cell lysates.

Calregulin (H-170) - sc-11398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Calregulin (H-170): sc-11398. Western blot analysis of Calregulin expression in HeLa (A) and SK-MEL-28 (B) whole cell lysates.

Calregulin (T-19) - sc-7431 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Calregulin (T-19): sc-7431. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

Calregulin (1G6A7) - sc-101436 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Calregulin (1G6A7): sc-101436. Western blot analysis of Calregulin expression in HeLa (A) and SK-MEL-28 (B) whole cell lysates.

Calregulin (N-19) - sc-6468 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Calregulin (N-19): sc-6468. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

Anti-Calreticulin antibody - ab2908 from Abcam

Prices $378.00
Sizes 100 µl
Host Chicken
Clonality Polyclonal
Western blot of calreticulin on HeLa cell extract using ab2908.

Anti-Calreticulin antibody - ab16144 from Abcam

Prices $378.00
Sizes 250 µg
Host Sheep
Clonality Polyclonal
All lanes : Anti-Calreticulin antibody (ab16144) at 1/5000 dilutionLane 1 : Whole cell lysate prepared from Human Jurkat cells at 2 µgLane 2 : Whole cell lysate prepared from MCF-7 cells at 2 µgLane 3 : Whole cell lysate prepared from Rat1 cells at 2 µgLane 4 : Whole cell lysate prepared from MDCK cellsLane 5 : Whole cell lysate prepared from MDCK cells Lane 6 : Whole cell lysate prepared from MDCK cells

Anti-Calreticulin antibody - ab19261 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Calreticulin antibody - ab4109 from Abcam

Prices $382.00
Sizes 50 µl
Host Goat
Clonality Polyclonal

Anti-Calreticulin antibody - ab70013 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Calreticulin antibody (ab70013) at 1/500 dilutionLane 1 : extracts from COS7 cellsLane 2 : extracts from COS7 cells with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Calreticulin antibody - ab90539 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Calreticulin antibody (ab90539) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : PC12 cell lysateLane 3 : 3T3 cell lysatedeveloped using the ECL technique

Anti-Calreticulin antibody - ab117586 from Abcam

Prices $378.00
Sizes 125 µg
Host Sheep
Clonality Polyclonal
Formalin-fixed, paraffin-embedded Human thyroid tissue labelled with ab117586 at 5 µg/ml

Anti-Calreticulin antibody - ab54922 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Calreticulin antibody (ab54922) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human colon tissue.

Anti-Calreticulin antibody - ab72508 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Calreticulin antibody (ab72508) at 0.04 µg/mlLane 1 : Whole cell lysate from Hela cells at 50 µgLane 2 : Whole cell lysate from Hela cells at 15 µgLane 3 : Whole cell lysate from Hela cells at 5 µgLane 4 : Whole cell lysate from 293T cells at 50 µgLane 5 : Whole cell lysate from NIH3T3 cells at 50 µgdeveloped using the ECL technique

Anti-Calreticulin antibody [1G6A7] - ab130189 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G6A7
All lanes : Anti-Calreticulin antibody [1G6A7] (ab130189) at 1/500 dilutionLane 1 : Hela cell lysateLane 2 : A549 cell lysateLane 3 : NTERA2 cell lysateLane 4 : MCF-7 cell lysate

Anti-Calreticulin antibody [EPR3924] - ER Marker - ab92516 from Abcam

Prices $388.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3924
All lanes : Anti-Calreticulin antibody [EPR3924] - ER Marker (ab92516) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HL-60 cell lysateLane 3 : HepG2 cell lysateLane 4 : HeLa cell lysateLane 5 : Fetal kidney lysateLane 6 : Fetal brain lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Calreticulin antibody [EPR3924] - ER Marker (Alexa Fluor® 488) - ab196158 from Abcam

Prices $431.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3924
Overlay histogram showing HeLa cells stained with ab196158 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab196158, 1/50 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 488 used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control.Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.This antibody gave a positive signal in HeLa fixed with 4% formaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Calreticulin antibody [EPR3924] - ER Marker (Alexa Fluor® 647) - ab196159 from Abcam

Prices $431.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3924
ab196159 staining Calreticulin in HeLa cells. The cells were fixed with 100% methanol (5 min), permeabiliszd in 0.1% Triton X-100 for 5 minutes and then blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with ab196159 at 1/100 dilution (shown in red) and ab195887, Mouse monoclonal [DM1A] to alpha Tubulin (Alexa Fluor® 488, shown in green) at 2µg/ml overnight at +4°C. Nuclear DNA was labelled in blue with DAPI.Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Calreticulin antibody [EPR3924] - ER Marker (HRP) - ab195511 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3924
All lanes : Anti-Calreticulin antibody [EPR3924] - ER Marker (HRP) (ab195511) at 1/5000 dilutionLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate (ab150035)Lane 3 : Brain (Human) Tissue Lysate - fetal normal tissueLysates/proteins at 10 µg per lane.developed using the ECL techniquePerformed under reducing conditions.

Anti-Calreticulin antibody [EPR3925] - ER Marker - ab108395 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3925
All lanes : Anti-Calreticulin antibody [EPR3925] - ER Marker (ab108395) at 1/1000 dilutionLane 1 : Fetal brainLane 2 : Fetal kidneyLane 3 : NIH 3T3 cell lysates Lysates/proteins at 10 µg per lane.
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