| Gene Symbol |
Mas1
|
| Entrez Gene |
17171
|
| Alt Symbol |
Mas-1, Mgra
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
MAS1 oncogene
|
| Other Description |
MAS proto-oncogene|Mas-related G protein-coupled receptor a|angiotensin-(1-7) receptor|proto-oncogene Mas
|
| Swissprots |
O35944 Q8BHI8 P30554
|
| Accessions |
CAA47964 CDG86213 EDL02043 EDL02044 P30554 AK015036 BAB29684 AK030261 BAC26865 AK030265 BAC26868 BB262893 BC120790 AAI20791 BC125537 AAI25538 BC144900 AAI44901 U96273 AAB69120 XM_006523293 XP_006523356 XM_006523294 XP_006523357 XM_006523296 XP_006523359 XM_006523297 XP_006523360 XM_006523299 XP_006523362 XM_011246190 XP_011244492 XM_011246191 XP_011244493 XM_011246192 XP_011244494 XM_011246193 XP_011244495 XM_011246194 XP_011244496 NM_008552 NP_032578
|
| Function |
Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (By similarity). Receptor for angiotensin 1-7. {ECO:0000250, ECO:0000269|PubMed:12829792}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Renin-angiotensin system, Neuroactive ligand-receptor interaction
|