| Gene Symbol |
Gadd45a
|
| Entrez Gene |
25112
|
| Alt Symbol |
Ddit1, Gadd45
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
growth arrest and DNA-damage-inducible, alpha
|
| Other Description |
DDIT-1|DNA damage-inducible transcript 1 protein|DNA-damage-inducible transcript 1|growth arrest and DNA damage-inducible protein GADD45 alpha|growth arrest and DNA-damage-inducible 45 alpha|growth arrest and DNA-damage-inducible protein GADD45 alpha
|
| Swissprots |
P48317
|
| Accessions |
AAB02030 EDL91582 P48317 AB102787 BAG30818 AB102788 BAG30819 BC081795 AAH81795 L32591 AAA96332 NM_024127 NP_077041
|
| Function |
Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Cell cycle, p53 signaling pathway, MAPK signaling pathway
|