FOXA1

Gene Symbol FOXA1
Entrez Gene 3169
Alt Symbol HNF3A, TCF3A
Species Human
Gene Type protein-coding
Description forkhead box A1
Other Description HNF-3-alpha|HNF-3A|TCF-3A|forkhead box protein A1|hepatocyte nuclear factor 3-alpha|transcription factor 3A
Swissprots B2R9H6 P55317 B7ZAP5 Q9H2A0
Accessions AAD51979 AAG40847 EAW65844 P55317 AK304119 BAG65019 AK313785 BAG36523 AK316360 BAH14731 AM392863 CAL37741 AM393239 CAL38117 AM393310 CAL38188 AM393369 CAL38247 BC033890 AAH33890 BM970983 BU860564 DA705947 U39840 AAB06493 NM_004496 NP_004487
Function Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activit
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.
Tissue Specificity Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas. {ECO:0000269|PubMed:12234996, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.

FOXA1 overexpression lysate - LY401427 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

FOXA1 293 Cell Lysate - 401299 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

HNF-3 alpha/FoxA1 Overexpression Lysate (Native) - NBL1-10798 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

HNF-3α (h2): 293T Lysate - sc-128813 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

FOXA1 Over-expression Lysate Product - GWB-45DB34 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human FOXA1 Knockdown Stable Cell Line - CSC-DC005835 from Creative biogene

Category Cell Line
Species Human

FOXA1 Knockout Cell Line-HeLa - CSC-RT1915 from Creative biogene

Category Cell Line
Species Human

FOXA1 KO Cell Lysate-HeLa - CLKO-1771 from Creative biogene

Category Cell Lysate
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