| Gene Symbol |
AJUBA
|
| Entrez Gene |
84962
|
| Alt Symbol |
JUB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ajuba LIM protein
|
| Other Description |
LIM domain-containing protein ajuba|jub, ajuba homolog
|
| Swissprots |
D3DS37 Q96IF1 A8MX18
|
| Accessions |
EAW66204 EAW66205 Q96IF1 AA909473 AK025567 AK096128 BAG53217 AW615335 AY169959 AAO37641 BC007580 AAH07580 BC016733 BC034968 AAH34968 BU543883 BX109281 CB105505 DQ893513 ABM84439 DQ896486 ABM87485 NM_001289097 NP_001276026 NM_032876 NP_116265 NM_198086 NP_932352
|
| Function |
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell- cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1- induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin tr
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.
|
| Top Pathways |
Hippo signaling pathway
|