CRK

Gene Symbol CRK
Entrez Gene 1398
Alt Symbol CRKII, p38
Species Human
Gene Type protein-coding
Description v-crk avian sarcoma virus CT10 oncogene homolog
Other Description adapter molecule crk|proto-oncogene c-Crk
Swissprots Q96HJ0 A8MWE8 Q96GA9 D3DTH6 B0LPE8 P46108
Accessions AAB28213 ABY87527 AGC09588 EAW90621 EAW90622 EAW90623 EAW90624 EAW90625 EAW90626 P46108 AK095449 AK291060 BAF83749 AU125411 BC001718 AAH01718 BC008506 AAH08506 BC009837 AAH09837 BT007277 AAP35941 D10656 BAA01505 DQ891147 ABM82073 DQ894327 ABM85253 NM_005206 NP_005197 NM_016823 NP_058431
Function The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
Top Pathways Rap1 signaling pathway, Bacterial invasion of epithelial cells, Chemokine signaling pathway, MicroRNAs in cancer, Focal adhesion