CRK

Gene Symbol CRK
Entrez Gene 1398
Alt Symbol CRKII, p38
Species Human
Gene Type protein-coding
Description v-crk avian sarcoma virus CT10 oncogene homolog
Other Description adapter molecule crk|proto-oncogene c-Crk
Swissprots Q96HJ0 A8MWE8 Q96GA9 D3DTH6 B0LPE8 P46108
Accessions AAB28213 ABY87527 AGC09588 EAW90621 EAW90622 EAW90623 EAW90624 EAW90625 EAW90626 P46108 AK095449 AK291060 BAF83749 AU125411 BC001718 AAH01718 BC008506 AAH08506 BC009837 AAH09837 BT007277 AAP35941 D10656 BAA01505 DQ891147 ABM82073 DQ894327 ABM85253 NM_005206 NP_005197 NM_016823 NP_058431
Function The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
Top Pathways Rap1 signaling pathway, Bacterial invasion of epithelial cells, Chemokine signaling pathway, MicroRNAs in cancer, Focal adhesion

CRK-Over-expression-Lysate - LY11439a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CRK (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CRK gene

CRK overexpression lysate - LY417443 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

CRK 293 Cell Lysate - 402254 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Disease Cancer

CRK 293 Cell Lysate - 408158 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Disease Cancer

Crk Overexpression Lysate (Native) - NBL1-09484 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Crk Overexpression Lysate (Adult Normal) [NBL1-09484] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Crk.

Crk Overexpression Lysate (Native) - NBL1-09483 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Crk Overexpression Lysate (Adult Normal) [NBL1-09483] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Crk.

Crk II (h): 293 Lysate - sc-110474 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Crk II (h): 293T Lysate - sc-159757 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

CRK Over-expression Lysate Product - GWB-37B7E4 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

CRK Over-expression Lysate Product - GWB-306905 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Crk Overexpression Lysate (Denatured) - H00001398-T02 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human CRK Knockdown Stable Cell Line - CSC-DC003650 from Creative biogene

Category Cell Line
Species Human
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