KPNB1
| Gene Symbol | KPNB1 |
|---|---|
| Entrez Gene | 3837 |
| Alt Symbol | IMB1, IPO1, IPOB, Impnb, NTF97 |
| Species | Human |
| Gene Type | protein-coding |
| Description | karyopherin (importin) beta 1 |
| Other Description | PTAC97|importin 1|importin 90|importin beta-1 subunit|importin subunit beta-1|importin-90|karyopherin subunit beta-1|nuclear factor p97|pore targeting complex 97 kDa subunit |
| Swissprots | Q96J27 Q14637 Q53XN2 D3DTT3 Q14974 B7ZAV6 |
| Accessions | AAA82869 CAM84939 EAW94807 EAW94808 EAW94809 EAW94810 Q14974 AI076614 AK299145 BAH12957 AK301463 BAH13488 AK314780 BAG37316 AK316421 BAH14792 BC003572 AAH03572 BC024045 AAH24045 BC036703 AAH36703 BE046507 BQ009884 BT009797 AAP88799 DB083013 DQ892863 ABM83789 DQ896112 ABM87111 L38951 AAC41763 L39924 NM_001276453 NP_001263382 NM_002265 NP_002256 |
| Function | Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal prot |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11891849}. Nucleus envelope {ECO:0000269|PubMed:11891849}. |
| Top Pathways | RNA transport |
karyopherin β1 siRNA (h) - sc-35736 from Santa Cruz Biotechnology
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karyopherin β1 shRNA Plasmid (h) - sc-35736-SH from Santa Cruz Biotechnology
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karyopherin β1 shRNA (h) Lentiviral Particles - sc-35736-V from Santa Cruz Biotechnology
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Importin beta/KPNB1 RNAi - H00003837-R01 from Novus Biologicals
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MISSION® esiRNA - EHU043151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11344 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11344 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08842 from Sigma-Aldrich
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KPNB1 siRNA (Human) - CRH2600 from Cohesion Biosciences
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shRNA set against Human KPNB1 (NM_002265.4) - SHH327063 from Creative biogene
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shRNA set against Human KPNB1(NM_002265.4) - SHL204456 from Creative biogene
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Human KPNB1 siRNA - orb263102 from Biorbyt
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KPNB1 shRNA Plasmid (Human) - CHH2600 from Cohesion Biosciences
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KPNB1 miRNA 3'UTR clone - MiUTR1H-05427 from Creative biogene
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