| Gene Symbol |
EPHA5
|
| Entrez Gene |
2044
|
| Alt Symbol |
CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EPH receptor A5
|
| Other Description |
EPH homology kinase 1|EPH-like kinase 7|brain-specific kinase|ephrin type-A receptor 5|receptor protein-tyrosine kinase HEK7|tyrosine-protein kinase receptor EHK-1
|
| Swissprots |
Q7Z3F2 P54756
|
| Accessions |
EAX05536 EAX05537 EAX05538 EAX05539 P54756 AB209375 BAD92612 AK307826 AM393049 CAL37927 AM393488 CAL38365 BC136257 AAI36258 BC136258 AAI36259 BC143427 AAI43428 BX537946 CAD97914 L36644 AAA74245 XM_005265653 XP_005265710 XM_011531733 XP_011530035 XM_011531734 XP_011530036 XM_011531735 XP_011530037 XM_011531736 XP_011530038 NM_001281765 NP_001268694 NM_001281766 NP_001268695 NM_001281767 NP_001268696 NM_004439 NP_004430 NM_182472 NP_872272
|
| Function |
Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
|
| Tissue Specificity |
Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord. {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
|
| Top Pathways |
Axon guidance
|