| Gene Symbol |
HIPK1
|
| Entrez Gene |
204851
|
| Alt Symbol |
Myak, Nbak2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
homeodomain interacting protein kinase 1
|
| Other Description |
homeodomain interacting protein kinase 1-like protein|homeodomain-interacting protein kinase 1|nuclear body associated kinase 2b|nuclear body-associated kinase 2
|
| Swissprots |
A6NJ34 Q8NDN5 Q5SQL5 Q8TBZ1 Q8NEB6 Q5SQL4 Q5SQL2 Q8IYD7 O75125 Q86Z02
|
| Accessions |
EAW56585 EAW56586 EAW56587 EAW56588 EAW56589 EAW56590 EAW56591 EAW56592 EAW56593 Q86Z02 AA995033 AB014530 BAA31605 AB089957 BAC57075 AK122662 BAG53650 AK302726 BAG63945 AL833829 CAD38689 BC028408 AAH28408 BC033012 AAH33012 BC033339 BC036057 AAH36057 BC052493 XM_005270609 XP_005270666 XM_005270610 XP_005270667 XM_005270611 XP_005270668 XM_005270612 XP_005270669 XM_005270613 XP_005270670 XM_006710443 XP_006710506 XM_011540977 XP_011539279 XM_011540978 XP_011539280 XM_011540979 XP_011539281 XM_011540980 XP_011539282 NM_152696 NP_689909 NM_181358 NP_852003 NM_198268 NP_938009 NM_198269 NP_938010
|
| Function |
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:00
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation.
|
| Tissue Specificity |
Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. {ECO:0000269|PubMed:12529400, ECO:0000269|PubMed:12702766}.
|