| Gene Symbol |
AP1S1
|
| Entrez Gene |
1174
|
| Alt Symbol |
AP19, CLAPS1, EKV3, MEDNIK, SIGMA1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adaptor-related protein complex 1, sigma 1 subunit
|
| Other Description |
AP-1 complex subunit sigma-1A|HA1 19 kDa subunit|adapter-related protein complex 1 sigma-1A subunit|adaptor protein complex AP-1 subunit sigma-1A|adaptor-related protein complex 1 subunit sigma-1A|clathrin assembly protein complex 1 sigma-1A small chain|clathrin coat assembly protein AP19|clathrin-associated/assembly/adaptor protein, small 1 (19kD)|golgi adaptor HA1/AP1 adaptin sigma-1A subunit|sigma1A subunit of AP-1 clathrin adaptor complex|sigma1A-adaptin
|
| Swissprots |
B2R5D8 Q9UDW9 Q9BTN4 Q53YA7 Q00382 P82267 P61966
|
| Accessions |
AAD45829 EAW50198 EAW50199 EAW50200 P61966 AB015319 BAA33391 AK312151 BAG35085 BC003561 AAH03561 BI597121 BI598615 BI857465 BT006779 AAP35425 NM_001283 NP_001274 NM_057089
|
| Function |
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:9733768}.
|
| Subcellular Location |
Golgi apparatus {ECO:0000269|PubMed:9733768}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9733768}; Peripheral membrane protein {ECO:0000269|PubMed:9733768}; Cytoplasmic side {ECO:0000269|PubMed:9733768}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:9733768}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:9733768}.
|
| Top Pathways |
Lysosome
|