| Gene Symbol | Epcam |
|---|---|
| Entrez Gene | 171577 |
| Alt Symbol | Egp314, Tacstd1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | epithelial cell adhesion molecule |
| Other Description | ep-CAM|epithelial glycoprotein 314|tumor-associated calcium signal transducer 1 |
| Swissprots | O55159 |
| Accessions | EDM02636 O55159 AJ001044 CAA04498 BC061787 BC072691 AAH72691 FQ229377 NM_138541 NP_612550 |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). {ECO:0000250}. |
| Subcellular Location | Lateral cell membrane {ECO:0000269|PubMed:16054130}; Single-pass type I membrane protein {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. |