Aco1

Gene Symbol Aco1
Entrez Gene 11428
Alt Symbol Aco-1, Irebp, Irp1
Species Mouse
Gene Type protein-coding
Description aconitase 1
Other Description IRE-BP 1|citrate hydro-lyase|cytoplasmic aconitase|cytoplasmic aconitate hydratase|iron regulatory protein 1|iron-responsive element-binding protein 1
Swissprots Q99K54 Q3TQ15 P28271
Accessions CAD20353 EDL05446 P28271 AK027914 AK085951 AK129025 AK163985 BAE37570 AK178044 AK178972 AK187955 AK194174 AK201556 AK207292 AK216262 BB854442 BC005454 AAH05454 BC020360 BY145469 X61147 CAA43455 NM_007386 NP_031412
Function Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm.
Top Pathways Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism

IRP-1 CRISPR/Cas9 KO Plasmid (m) - sc-418946 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRP-1 HDR Plasmid (m) - sc-418946-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRP-1 Double Nickase Plasmid (m) - sc-418946-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRP-1 Double Nickase Plasmid (m2) - sc-418946-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRP-1 CRISPR Activation Plasmid (m) - sc-418946-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRP-1 CRISPR Activation Plasmid (m2) - sc-418946-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRP-1 Lentiviral Activation Particles (m) - sc-418946-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRP-1 Lentiviral Activation Particles (m2) - sc-418946-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRP-1 siRNA (m) - sc-40714 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

IRP-1 shRNA Plasmid (m) - sc-40714-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

IRP-1 shRNA (m) Lentiviral Particles - sc-40714-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU083911 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN26155 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26155 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ACO1 siRNA (Mouse) - CRM0020 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ACO1 - MBS8207527 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse ACO1 (NM_007386.2) - SHH230342 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Aco1(NM_007386.2) - SHG029737 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse ACO1 siRNA - orb279496 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ACO1 shRNA Plasmid (Mouse) - CHM0020 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

ACO1 miRNA 3'UTR clone - MiUTR1M-01115 from Creative biogene

Species Reactivities Mouse
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