| Gene Symbol | CCR4 |
|---|---|
| Entrez Gene | 1233 |
| Alt Symbol | CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) receptor 4 |
| Other Description | C-C CKR-4|C-C chemokine receptor type 4|CCR-4|chemokine (C-C) receptor 4 |
| Swissprots | Q9ULY7 Q9ULY6 P51679 |
| Accessions | AAP84352 ABK41942 BAA86965 BAA86966 BAA86967 BAA86968 BAA86969 EAW64440 EAW64441 P51679 AK292674 BAF85363 BC069139 AAH69139 BC071751 AAH71751 BC074935 AAH74935 CD639869 CD640816 NM_005508 NP_005499 |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10466728, ECO:0000269|PubMed:10754297, ECO:0000269|PubMed:16137713, ECO:0000269|PubMed:9169480, ECO:0000269|PubMed:9430724}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. {ECO:0000269|PubMed:10754297}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Viral carcinogenesis |