CCR4
| Gene Symbol | CCR4 |
|---|---|
| Entrez Gene | 1233 |
| Alt Symbol | CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) receptor 4 |
| Other Description | C-C CKR-4|C-C chemokine receptor type 4|CCR-4|chemokine (C-C) receptor 4 |
| Swissprots | Q9ULY7 Q9ULY6 P51679 |
| Accessions | AAP84352 ABK41942 BAA86965 BAA86966 BAA86967 BAA86968 BAA86969 EAW64440 EAW64441 P51679 AK292674 BAF85363 BC069139 AAH69139 BC071751 AAH71751 BC074935 AAH74935 CD639869 CD640816 NM_005508 NP_005499 |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10466728, ECO:0000269|PubMed:10754297, ECO:0000269|PubMed:16137713, ECO:0000269|PubMed:9169480, ECO:0000269|PubMed:9430724}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. {ECO:0000269|PubMed:10754297}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Viral carcinogenesis |
CKR-4 CRISPR/Cas9 KO Plasmid (h) - sc-404778 from Santa Cruz Biotechnology
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CKR-4 HDR Plasmid (h) - sc-404778-HDR from Santa Cruz Biotechnology
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CKR-4 Double Nickase Plasmid (h) - sc-404778-NIC from Santa Cruz Biotechnology
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CKR-4 Double Nickase Plasmid (h2) - sc-404778-NIC-2 from Santa Cruz Biotechnology
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CKR-4 CRISPR Activation Plasmid (h) - sc-404778-ACT from Santa Cruz Biotechnology
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CKR-4 CRISPR Activation Plasmid (h2) - sc-404778-ACT-2 from Santa Cruz Biotechnology
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CKR-4 Lentiviral Activation Particles (h) - sc-404778-LAC from Santa Cruz Biotechnology
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CKR-4 Lentiviral Activation Particles (h2) - sc-404778-LAC-2 from Santa Cruz Biotechnology
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CKR-4 siRNA (h) - sc-39886 from Santa Cruz Biotechnology
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CKR-4 shRNA Plasmid (h) - sc-39886-SH from Santa Cruz Biotechnology
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CKR-4 shRNA (h) Lentiviral Particles - sc-39886-V from Santa Cruz Biotechnology
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CCR4 RNAi - H00001233-R02 from Novus Biologicals
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MISSION® esiRNA - EHU019891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5656 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5656 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02997 from Sigma-Aldrich
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CCR4 siRNA (Human) - CRH0869 from Cohesion Biosciences
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CCR4 - MBS8204821 from MyBioSource
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shRNA set against Human Ccr4 (NM_005508.4) - SHH258169 from Creative biogene
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shRNA set against Human CCR4(NM_005508.4) - SHG153389 from Creative biogene
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CCR4 shRNA Plasmid (Human) - CHH0869 from Cohesion Biosciences
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CCR4 miRNA 3'UTR clone - MiUTR1H-01826 from Creative biogene
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