| Gene Symbol |
Rpa1
|
| Entrez Gene |
68275
|
| Alt Symbol |
5031405K23Rik, 70kDa, AA589576, AW557552, RF-A, RP-A, Rpa
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
replication protein A1
|
| Other Description |
RF-A protein 1|RP-A p70|replication factor A protein 1|replication protein A 70 kDa DNA-binding subunit
|
| Swissprots |
Q3TEJ8 Q8VEE4
|
| Accessions |
EDL12800 Q8VEE4 AK014298 AK019864 AK035084 AK148035 BAE28302 AK150785 BAE29849 AK151590 BAE30530 AK152296 BAE31105 AK153107 AK153144 BAE31755 AK165316 BAE38134 AK165944 BAE38476 AK167598 BAE39655 AK168400 AK169599 BAE41250 AK177196 AK177907 AK178009 AK178914 AK179745 AK179927 AK180105 AK184031 AK184178 AK184637 AK185517 AK187897 AK189517 AK191496 AK191807 AK192557 AK194307 AK194339 AK194722 AK196134 AK196886 AK196893 AK197921 AK197958 AK198762 AK199793 AK199865 AK199942 AK201262 AK202480 AK202570 AK202801 AK203011 AK203654 AK204019 AK204740 AK204900 AK204963 AK205283 AK206408 AK206421 AK206519 AK206963 AK206973 AK207022 AK207092 AK207399 AK210768 AK211226 AK211282 AK212495 AK213326 AK214358 AK214387 AK215767 AK216001 AK216329 AK216701 AK216917 AK216964 AK217077 AK217218 AK217322 AK217357 AK218266 AK218731 AK219356 BC019119 AAH19119 BE981198 CJ078143 CJ086677 XM_006534051 XP_006534114 NM_001164223 NP_001157695 NM_026653 NP_080929
|
| Function |
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interacti
|
| Subcellular Location |
Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
|
| Top Pathways |
DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway
|