| Gene Symbol |
HNRNPK
|
| Entrez Gene |
528135
|
| Alt Symbol |
HNRPK
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
heterogeneous nuclear ribonucleoprotein K
|
| Other Description |
hnRNP K
|
| Swissprots |
Q3T0D0
|
| Accessions |
DAA26638 Q3T0D0 BC102450 AAI02451 XM_005210329 XP_005210386 XM_005210330 XP_005210387 XM_005210331 XP_005210388 XM_005210333 XP_005210390 XM_005210334 XP_005210391 XM_005210335 XP_005210392 XM_010808097 XP_010806399 NM_001034562 NP_001029734
|
| Function |
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non- coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cell projection, podosome {ECO:0000250}.
|
| Top Pathways |
Spliceosome, Herpes simplex infection, Viral carcinogenesis, MicroRNAs in cancer
|