| Gene Symbol | IL1B |
|---|---|
| Entrez Gene | 3553 |
| Alt Symbol | IL-1, IL1-BETA, IL1F2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 1, beta |
| Other Description | IL-1 beta|catabolin|interleukin-1 beta|preinterleukin 1 beta|pro-interleukin-1-beta |
| Swissprots | Q53X59 P01584 Q9UCT6 Q7RU01 Q7M4S7 Q96HE5 Q53XX2 |
| Accessions | AAA74137 AAM88883 AAX88888 CAA28185 CAD29872 CCA63968 EAW73605 EAW73606 EAW73607 P01584 AB451494 BAG70308 AF043335 AAC03536 AK313983 BC008678 AAH08678 BT007213 AAP35877 CR407679 CAG28607 DQ890673 ABM81599 DQ893854 ABM84780 K02770 AAA36106 M15330 AAA59135 M54933 AAA59136 X02532 CAA26372 X56087 CAA39567 XM_006712496 XP_006712559 NM_000576 NP_000567 |
| Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. {ECO:0000269|PubMed:3920526}. |
| Subcellular Location | Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
| Top Pathways | Herpes simplex infection, Tuberculosis, Legionellosis, TNF signaling pathway, Salmonella infection |