VAMP8

Gene Symbol VAMP8
Entrez Gene 8673
Alt Symbol EDB, VAMP-8
Species Human
Gene Type protein-coding
Description vesicle-associated membrane protein 8
Other Description vesicle-associated membrane protein 8 (endobrevin)
Swissprots Q6IB09 O60625 Q9BV40 Q53SP9
Accessions AAY24341 EAW99506 Q9BV40 AF053233 AAC08434 BC001634 AAH01634 BM702226 BQ227618 BT006700 AAP35346 BX092149 CD367710 CR456995 CAG33276 NM_003761 NP_003752
Function SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. {ECO:0000269|PubMed:12130530, ECO:0000269|PubMed:23217709}.
Subcellular Location Lysosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250}.
Tissue Specificity Platelets.
Top Pathways SNARE interactions in vesicular transport

Vesicle-associated membrane protein 8 (VAMP8), Human, ELISA Kit - CSB-EL025786HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Human Vesicle-associated membrane protein 8(VAMP8) ELISA kit - CSB-EL025786HU from Cusabio

Category ELISA Kit
Sensitivity 15.6 pg/ml
Range 62.5 pg/ml-4000 pg/ml

vesicle-associated membrane protein 8 (endobrevin) , ELISA Kit - MBS916105 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 15.6 pg/ml
Range 62.5 pg/ml-4000 pg/ml

Human VAMP8 ELISA Kit - E102418 from Biobool

Category ELISA Kit

VAMP8 ELISA Kit (Human) (OKCA00857) - OKCA00857 from Aviva Systems Biology

Category ELISA Kit
Prices $590.00
Sizes 96 wells
Sensitivity 15.6 pg/mL
Range 62.5 pg/mL-4,000 pg/mL

anti-VAMP8 antibody - ARG55005 from Arigo Biolaboratories

Category ELISA Kit

anti-VAMP8 antibody - ARG55006 from Arigo Biolaboratories

Category ELISA Kit

Human VAMP8 ELISA Kit - orb405536 from Biorbyt

Category ELISA Kit
Sensitivity 15.6 pg/ml
Range 62.5 pg/ml-4000 pg/ml
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