| Gene Symbol |
Ctcf
|
| Entrez Gene |
13018
|
| Alt Symbol |
AW108038
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
CCCTC-binding factor
|
| Other Description |
11-zinc finger protein|CTCFL paralog|transcriptional repressor CTCF
|
| Swissprots |
Q61164
|
| Accessions |
EDL11292 EDL11293 EDL11294 EDL11295 EDL11296 EDL11297 Q61164 AB221631 AK076192 BAC36245 AK132514 BAE21212 AK133842 BAE21879 AK134247 BAE22063 AK140164 BAE24263 AK205972 BC009129 BC024382 AAH24382 BC037456 AAH37456 BC046398 AAH46398 BC049131 AAH49131 BC058240 AAH58240 U51037 AAC52928 XM_006530644 XP_006530707 XM_006530645 XP_006530708 XM_006530646 XP_006530709 XM_006530647 XP_006530710 XM_006530648 XP_006530711 NM_181322 NP_851839
|
| Function |
Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000305|PubMed:8649389}. Chromosome {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase (By similarity). {ECO:0000250}.
|