EIF6

Gene Symbol EIF6
Entrez Gene 3692
Alt Symbol CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 6
Other Description B4 integrin interactor|eIF-6|eukaryotic translation initiation factor 3A|p27 beta-4 integrin-binding protein
Swissprots B7ZBG9 P56537 Q96TD5 Q6IBN8
Accessions AAK39426 CAI93602 EAW76219 EAW76220 EAW76221 P56537 AB062289 BAB93472 AF022229 AAB97735 AF047433 AAC39897 AF401207 AK296076 BAG58832 AK314969 BAG37470 AL537456 BC001119 AAH01119 BC011845 AAH11845 BC019305 AAH19305 BC095465 BG283650 BG334381 BM794263 BM851166 BQ222221 CN265282 CR456764 CAG33045 CT002623 DB448068 DQ892592 ABM83518 DQ895811 ABM86737 HG511334 Y11435 CAA72243 NM_001267810 NP_001254739 NM_002212 NP_002203 NM_181466 NP_852131 NM_181468 NP_852133 NR_052022 NR_052023 NR_052024 NM_181467 NM_181469
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:21536732}.
Subcellular Location Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Tissue Specificity Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level). {ECO:0000269|PubMed:11290417}.
Top Pathways Ribosome biogenesis in eukaryotes

eIF6 CRISPR/Cas9 KO Plasmid (h) - sc-406066 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF6 HDR Plasmid (h) - sc-406066-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF6 Double Nickase Plasmid (h) - sc-406066-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF6 Double Nickase Plasmid (h2) - sc-406066-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF6 CRISPR Activation Plasmid (h) - sc-406066-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF6 CRISPR Activation Plasmid (h2) - sc-406066-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF6 Lentiviral Activation Particles (h) - sc-406066-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF6 Lentiviral Activation Particles (h2) - sc-406066-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF6 siRNA (h) - sc-77255 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF6 shRNA Plasmid (h) - sc-77255-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF6 shRNA (h) Lentiviral Particles - sc-77255-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

integrin beta 4 binding protein RNAi - H00003692-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

integrin beta 4 binding protein RNAi - H00003692-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

integrin beta 4 binding protein RNAi - H00003692-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

integrin beta 4 binding protein RNAi - H00003692-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU099751 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7792 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7792 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EIF6 siRNA (Human) - CRH2481 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

integrin beta 4 binding protein RNAi - H00003692-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

EIF6 - MBS8239758 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EIF6 (NM_002212.3) - SHH284833 from Creative biogene

Category siRNA
Species Reactivities Human

Human EIF6 siRNA - orb262983 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF6 shRNA Plasmid (Human) - CHH2481 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EIF6 miRNA 3'UTR clone - MiUTR3H-05403 from Creative biogene

Species Reactivities Human
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