| Gene Symbol | EPHX2 |
|---|---|
| Entrez Gene | 2053 |
| Alt Symbol | CEH, SEH |
| Species | Human |
| Gene Type | protein-coding |
| Description | epoxide hydrolase 2, cytoplasmic |
| Other Description | bifunctional epoxide hydrolase 2|epoxide hydratase|epoxide hydrolase 2, cytosolic|epoxide hydrolase, soluble |
| Swissprots | J3KPH7 Q9HBJ2 Q9HBJ1 P34913 G3V134 Q16764 B3KUA0 B3KTU8 B2Z3B1 |
| Accessions | ACD11487 CAA65751 EAW63547 EAW63548 EAW63549 EAW63550 EAW63551 P34913 AF233334 AAG14966 AF233335 AAG14967 AF233336 AAG14968 AK094393 AK096089 BAG53210 AK096770 BAG53362 AK294065 BAG57410 AK303904 BAG64834 AK308041 AK310507 BC007708 AAH07708 BC011628 AAH11628 BC013874 AAH13874 BQ272362 BT006885 AAP35531 BX103698 CA397329 DC331720 DQ892749 ABM83675 DQ895995 ABM86963 L05779 AAA02756 NM_001256482 NP_001243411 NM_001256483 NP_001243412 NM_001256484 NP_001243413 NM_001979 NP_001970 |
| Function | Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate. {ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510}. |
| Subcellular Location | Cytoplasm. Peroxisome. |
| Top Pathways | Peroxisome, Arachidonic acid metabolism |