APH1B

Gene Symbol APH1B
Entrez Gene 83464
Alt Symbol APH-1B, PRO1328, PSFL, TAAV688
Species Human
Gene Type protein-coding
Description APH1B gamma secretase subunit
Other Description anterior pharynx defective 1 homolog B|aph-1beta|gamma-secretase subunit APH-1B
Swissprots Q9H0S0 A8K589 Q8WW43 Q564N3 Q6UWQ1
Accessions EAW77644 EAW77645 Q8WW43 AA808355 AB189172 BAD95573 AB197122 BAE02660 AF508794 AAN63817 AI693802 AK057677 AK291204 BAF83893 AK307456 AK307725 AK310843 AL136671 CAB66606 AM392724 CAL37602 AM392878 CAL37756 AY358698 AAQ89061 BC020905 AAH20905 BI825203 DA397427 DQ891401 ABM82327 XM_011522105 XP_011520407 NM_001145646 NP_001139118 NM_031301 NP_112591
Function Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. {ECO:0000269|PubMed:12297508}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12740439}.
Top Pathways Notch signaling pathway, Alzheimer's disease

Aph-1b (C-13) - sc-49358 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Aph-1b (H-80) - sc-134738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Aph-1b (H-80): sc-134738. Western blot analysis of Aph-1b expression in THP-1 (A), HeLa (B) and Jurkat (C) whole cell lysates.

Aph-1b (N-12) - sc-49359 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Aph-1b (S-17) - sc-49360 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Aph 1b antibody - ab116657 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Aph 1b antibody - ab24613 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Aph 1b antibody - ab128335 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Aph 1b antibody (ab128335) at 1 µg/ml + THP-1 cell lysate at 10 µgdeveloped using the ECL technique

Anti-APH1B Antibody (C-Terminus) - LS-C146519 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
APH1B antibody LS-C146519 Western blot of 1 Cell lysate. Antibody concentration 1 ug/ml.

Anti-APH1B Antibody (aa59-108) - LS-C201626 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Lung Tumor. APH1B antibody dilution 1.0 ug/ml.

APH1B Antibody - NBP1-98414 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Gamma-secretase subunit APH-1B Antibody [NBP1-98414] - THP-1 Cell Lysate 1.0ug/ml, Gel Concentration: 12%

Aph-1b Polyclonal Antibody - bs-11640R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded mouse testis tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-Aph-1b Polyclonal Antibody, Unconjugated (bs-11640R) at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining

Aph-1b Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11640R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11640R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11640R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11640R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, Cy3 Conjugated - bs-11640R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, Cy5 Conjugated - bs-11640R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, Cy5.5 Conjugated - bs-11640R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, Cy7 Conjugated - bs-11640R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, FITC Conjugated - bs-11640R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, Biotin Conjugated - bs-11640R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Aph-1b Polyclonal Antibody, HRP Conjugated - bs-11640R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-APH1B antibody produced in rabbit - SAB2107050 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-APH1B: <B>Cat. No. SAB2107050</B>: Western blot analysis of APH1B in THP-1 with APH1B (anterior pharynx defective 1 homolog B, C. elegans) antibody, against the C terminal of APH1B (50 μg) antibody at 1.0 μg/mL.

APH1B Antibody - N-terminal region (ARP53807_P050) - ARP53807_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APH1B antibody - C-terminal region (ARP53808_P050) - ARP53808_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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