Gene Symbol | APH1B |
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Entrez Gene | 83464 |
Alt Symbol | APH-1B, PRO1328, PSFL, TAAV688 |
Species | Human |
Gene Type | protein-coding |
Description | APH1B gamma secretase subunit |
Other Description | anterior pharynx defective 1 homolog B|aph-1beta|gamma-secretase subunit APH-1B |
Swissprots | Q9H0S0 A8K589 Q8WW43 Q564N3 Q6UWQ1 |
Accessions | EAW77644 EAW77645 Q8WW43 AA808355 AB189172 BAD95573 AB197122 BAE02660 AF508794 AAN63817 AI693802 AK057677 AK291204 BAF83893 AK307456 AK307725 AK310843 AL136671 CAB66606 AM392724 CAL37602 AM392878 CAL37756 AY358698 AAQ89061 BC020905 AAH20905 BI825203 DA397427 DQ891401 ABM82327 XM_011522105 XP_011520407 NM_001145646 NP_001139118 NM_031301 NP_112591 |
Function | Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. {ECO:0000269|PubMed:12297508}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12740439}. |
Top Pathways | Notch signaling pathway, Alzheimer's disease |
Aph-1b (C-13) - sc-49358 from Santa Cruz Biotechnology
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Aph-1b (H-80) - sc-134738 from Santa Cruz Biotechnology
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Aph-1b (N-12) - sc-49359 from Santa Cruz Biotechnology
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Aph-1b (S-17) - sc-49360 from Santa Cruz Biotechnology
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Anti-Aph 1b antibody - ab116657 from Abcam
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Anti-Aph 1b antibody - ab24613 from Abcam
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Anti-Aph 1b antibody - ab128335 from Abcam
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Anti-APH1B Antibody (C-Terminus) - LS-C146519 from LifeSpan Bioscience
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Anti-APH1B Antibody (aa59-108) - LS-C201626 from LifeSpan Bioscience
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APH1B Antibody - NBP1-98414 from Novus Biologicals
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Aph-1b Polyclonal Antibody - bs-11640R from Bioss
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Aph-1b Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11640R-A350 from Bioss
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Aph-1b Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11640R-A488 from Bioss
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Aph-1b Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11640R-A555 from Bioss
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Aph-1b Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11640R-A647 from Bioss
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Aph-1b Polyclonal Antibody, Cy3 Conjugated - bs-11640R-Cy3 from Bioss
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Aph-1b Polyclonal Antibody, Cy5 Conjugated - bs-11640R-Cy5 from Bioss
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Aph-1b Polyclonal Antibody, Cy5.5 Conjugated - bs-11640R-Cy5.5 from Bioss
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Aph-1b Polyclonal Antibody, Cy7 Conjugated - bs-11640R-Cy7 from Bioss
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Aph-1b Polyclonal Antibody, FITC Conjugated - bs-11640R-FITC from Bioss
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Aph-1b Polyclonal Antibody, Biotin Conjugated - bs-11640R-Biotin from Bioss
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Aph-1b Polyclonal Antibody, HRP Conjugated - bs-11640R-HRP from Bioss
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Anti-APH1B antibody produced in rabbit - SAB2107050 from Sigma-Aldrich
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APH1B Antibody - N-terminal region (ARP53807_P050) - ARP53807_P050 from Aviva Systems Biology
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APH1B antibody - C-terminal region (ARP53808_P050) - ARP53808_P050 from Aviva Systems Biology
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