| Gene Symbol |
Kcnj11
|
| Entrez Gene |
83535
|
| Alt Symbol |
Kir6.2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, inwardly rectifying subfamily J, member 11
|
| Other Description |
ATP-sensitive inward rectifier potassium channel 11|BIR|inward rectifier K(+) channel Kir6.2|potassium channel, inwardly rectifying subfamily J member 11|potassium inwardly rectifying channel, subfamily J, member 11|potassium inwardly-rectifying channel subfamily J member 11
|
| Swissprots |
P70673 Q62906 Q9JM48
|
| Accessions |
EDM07273 P70673 AB043638 BAA96239 AW527189 BF565039 D61687 BAA23630 U44897 AAB01810 X97041 CAA65754 XM_008759421 XP_008757643 NM_031358 NP_112648
|
| Function |
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Top Pathways |
Type II diabetes mellitus
|