| Gene Symbol |
Ggt5
|
| Entrez Gene |
23887
|
| Alt Symbol |
AI551243, GGL, GGT-REL, Ggtla1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
gamma-glutamyltransferase 5
|
| Other Description |
GGT 5|gamma-glutamyl leukotrienase|gamma-glutamyltransferase-like activity 1|gamma-glutamyltranspeptidase 5|glutathione hydrolase 5|leukotriene-C4 hydrolase
|
| Swissprots |
Q8C7B4 Q9Z2A9
|
| Accessions |
EDL31898 EDL31899 EDL31900 EDL31901 Q9Z2A9 AF077765 AAC71001 AK029138 BAC26318 AK049084 AK052183 BAC34873 AK085788 AK140308 AK170326 BAE41720 BC051971 AAH51971 BC089585 BC113775 AAI13776 XM_006513647 XP_006513710 XM_006513648 XP_006513711 XM_006513649 XP_006513712 NM_011820 NP_035950
|
| Function |
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Very low level of expression. Detected in spleen lymphocytes, medullary and paracortical thymic lymphocytes, lung interstitial cells, bronchial epithelium, proximal tubules in kidney, crypt cells in small intestine, neurons in brain stem and cerebral cortex and in Purkinje cells.
|
| Top Pathways |
Taurine and hypotaurine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Cyanoamino acid metabolism
|
