COL4A4

Gene Symbol COL4A4
Entrez Gene 1286
Alt Symbol CA44
Species Human
Gene Type protein-coding
Description collagen, type IV, alpha 4
Other Description Collagen IV, alpha-4 polypeptide|collagen alpha-4(IV) chain|collagen of basement membrane, alpha-4 chain
Swissprots A8MTZ1 Q53WR1 Q53RW9 Q53S42 P53420
Accessions AAY14670 AAY24061 BAA25065 CAA76763 EAW70845 EAW70846 EAW70847 P53420 AA831056 BC065843 BX094848 D17391 BAA04214 X81053 CAA56943 XM_005246281 XP_005246338 XM_005246282 XP_005246339 XM_006712246 XP_006712309 XM_006712249 XP_006712312 XM_006712251 XP_006712314 XM_006712252 XP_006712315 XM_011510557 XP_011508859 XM_011510558 XP_011508860 XM_011510559 XP_011508861 XM_011510560 XP_011508862 XM_011510561 XP_011508863 XM_011510562 XP_011508864 XM_011510563 XP_011508865 XM_011510564 XP_011508866 XM_011510565 XP_011508867 XM_011510566 XP_011508868 XM_011510567 XP_011508869 XM_011510568 XP_011508870 XM_011510569 XP_011508871 XM_011510570 XP_011508872 XM_011510571 XP_011508873 XM_011510572 XP_011508874 XR_922837 XR_922838 XR_922839 XR_922840 NM_000092 NP_000083
Function Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000255|PROSITE-ProRule:PRU00736}. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}.
Tissue Specificity Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. Highest levels of expression of alpha 4 type IV collagen are detected in kidney, calvaria, neuroretina and cardiac muscle. Lower levels of expression are observed in brain, lung and thymus, and no expression is detected in choroid plexus, liver, adrenal, pancreas, ileum or skin. {ECO:0000269|PubMed:7523402, ECO:0000269|PubMed:8083201}.
Top Pathways Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Protein digestion and absorption

COL4A4 CRISPR/Cas9 KO Plasmid (h) - sc-404186 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A4 HDR Plasmid (h) - sc-404186-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A4 Double Nickase Plasmid (h) - sc-404186-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A4 Double Nickase Plasmid (h2) - sc-404186-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A4 CRISPR Activation Plasmid (h) - sc-404186-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A4 CRISPR Activation Plasmid (h2) - sc-404186-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A4 Lentiviral Activation Particles (h) - sc-404186-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A4 Lentiviral Activation Particles (h2) - sc-404186-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A4 siRNA (h) - sc-94626 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COL4A4 shRNA Plasmid (h) - sc-94626-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COL4A4 shRNA (h) Lentiviral Particles - sc-94626-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN6393 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6393 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

COL4A4 siRNA (Human) - CRH0900 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COL4A4 - MBS8224367 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COL4A4 (NM_000092.4) - SHH267309 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human COL4A4(NM_000092.4) - SHG190671 from Creative biogene

Category siRNA
Species Reactivities Human

Human COL4A4 siRNA - orb261402 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COL4A4 shRNA Plasmid (Human) - CHH0900 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COL4A4 miRNA 3'UTR clone - MiUTR1H-02322 from Creative biogene

Species Reactivities Human
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