| Gene Symbol | EIF3E |
|---|---|
| Entrez Gene | 3646 |
| Alt Symbol | EIF3-P48, EIF3S6, INT6, eIF3-p46 |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 3, subunit E |
| Other Description | eIF-3 p48|eukaryotic translation initiation factor 3 subunit 6|eukaryotic translation initiation factor 3 subunit E|eukaryotic translation initiation factor 3, subunit 6 (48kD)|eukaryotic translation initiation factor 3, subunit 6 48kDa|mammary tumor-associated protein INT6|murine mammary tumor integration site 6 (oncogene homolog)|viral integration site protein INT-6 homolog |
| Swissprots | P60228 Q8WVK4 Q6FG33 Q64058 O43902 Q64252 Q64059 |
| Accessions | AAC51917 EAW91918 EAW91919 P60228 AK124178 BAG54018 AK310902 AK313186 BAG36003 BC000734 AAH00734 BC005944 BC008419 AAH08419 BC016706 AAH16706 BC017887 AAH17887 BC021679 AAH21679 BG498300 CR457029 CAG33310 CR542275 CAG47071 DQ892278 ABM83204 DQ895478 ABM86404 U54562 AAC51760 U62962 AAB58251 U85947 AAB88873 U94175 AAC51919 NM_001568 NP_001559 |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense- mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMe |
| Subcellular Location | Cytoplasm. Nucleus, PML body. |
| Tissue Specificity | Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus. {ECO:0000269|PubMed:8688078, ECO:0000269|PubMed:9295280}. |
| Top Pathways | RNA transport, Hepatitis C |