EIF3E

Gene Symbol	EIF3E
Entrez Gene	3646
Alt Symbol	EIF3-P48, EIF3S6, INT6, eIF3-p46
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 3, subunit E
Other Description	eIF-3 p48|eukaryotic translation initiation factor 3 subunit 6|eukaryotic translation initiation factor 3 subunit E|eukaryotic translation initiation factor 3, subunit 6 (48kD)|eukaryotic translation initiation factor 3, subunit 6 48kDa|mammary tumor-associated protein INT6|murine mammary tumor integration site 6 (oncogene homolog)|viral integration site protein INT-6 homolog
Swissprots	P60228 Q8WVK4 Q6FG33 Q64058 O43902 Q64252 Q64059
Accessions	AAC51917 EAW91918 EAW91919 P60228 AK124178 BAG54018 AK310902 AK313186 BAG36003 BC000734 AAH00734 BC005944 BC008419 AAH08419 BC016706 AAH16706 BC017887 AAH17887 BC021679 AAH21679 BG498300 CR457029 CAG33310 CR542275 CAG47071 DQ892278 ABM83204 DQ895478 ABM86404 U54562 AAC51760 U62962 AAB58251 U85947 AAB88873 U94175 AAC51919 NM_001568 NP_001559
Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense- mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMe
Subcellular Location	Cytoplasm. Nucleus, PML body.
Tissue Specificity	Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus. {ECO:0000269|PubMed:8688078, ECO:0000269|PubMed:9295280}.
Top Pathways	RNA transport, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human eIF3e full length protein - ab114769 from Abcam Category Protein Source Wheat germ Species Human

Human eIF3e peptide - ab36902 from Abcam Category Peptide

Human eIF3e protein fragment - ab114770 from Abcam Category Protein Source Wheat germ Species Human

EIF3E Antibody Blocking Peptide - LS-E27538 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EIF3E Antibody Blocking Peptide - LS-E17427 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EIF3E Antibody Blocking Peptide - LS-E17426 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EIF3E Antibody Blocking Peptide - LS-E6616 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human eIF3e Protein - H00003646-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

eIF3e Recombinant Protein - H00003646-P01 from Novus Biologicals Category Protein Species Human

EIF3E-AntibodyCenter-Blocking-peptide - BP19409c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EIF3E Blocking Peptide - 33R-5232 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EIF3E Blocking Peptide - 33R-2557 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

eIF3e Peptide - AC21-2360-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

EIF3E / EIF3S6 - H00003646-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

EIF3E / EIF3S6 - H00003646-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EIF3E / EIF3S6 - H00003646-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EIF3E / EIF3S6 - H00003646-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EIF3E Peptide - 42-702P from ProSci Category Peptide Species Human

EIF3E fusion protein - ag1132 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

EIF3E fusion protein - ag1856 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human EIF3E - EIF3E-26384TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human EIF3E - EIF3E-26385TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Pongo abelii Eukaryotic translation initiation factor 3 subunit E(EIF3E) - CSB-YP728972PYX CSB-EP728972PYX CSB-BP728972PYX CSB-MP728972PYX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Orangutan

Recombinant Eukaryotic translation initiation factor 3 subunit E(eif-3.E) - CSB-YP007534CXX CSB-EP007534CXX CSB-BP007534CXX CSB-MP007534CXX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Caenorhabditis

Recombinant Human Eukaryotic translation initiation factor 3 subunit E(EIF3E) - CSB-YP007534HU CSB-EP007534HU CSB-BP007534HU CSB-MP007534HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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