GRM2

Gene Symbol GRM2
Entrez Gene 2912
Alt Symbol GLUR2, GPRC1B, MGLUR2, mGlu2
Species Human
Gene Type protein-coding
Description glutamate receptor, metabotropic 2
Other Description glutamate metabotropic receptor 2|glutamate receptor homolog|metabotropic glutamate receptor 2
Swissprots Q52MC6 Q14CU5 Q9H3N6 B0M0K7 Q14416
Accessions BAB19817 EAW65150 Q14416 AB209164 BAD92401 AK289984 BAF82673 AK302671 BAG63904 AK313056 AK315816 BAF98707 AY999299 AAY14640 BC041447 AAH41447 BC113615 AAI13616 BC113619 AAI13620 BX648951 DA391442 EU432122 ABY87921 HQ258674 ADR83425 L35318 AAA76855 XM_011533635 XP_011531937 XM_011533636 XP_011531938 XM_011533637 XP_011531939 XM_011533638 XP_011531940 XM_011533639 XP_011531941 XM_011533640 XP_011531942 XM_011533641 XP_011531943 XM_011533642 XP_011531944 XM_011533643 XP_011531945 XM_011533644 XP_011531946 XM_011533645 XP_011531947 XM_011533646 XP_011531948 XM_011533647 XP_011531949 XR_940421 NM_000839 NP_000830 NM_001130063 NP_001123535
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:7620613}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. {ECO:0000269|PubMed:18297054}.
Top Pathways Glutamatergic synapse, Cocaine addiction, Neuroactive ligand-receptor interaction

mGluR-2 (A-1) - sc-271654 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
mGluR-2 (A-1): sc-271654. Western blot analysis of mGluR-2 expression in LNCaP whole cell lysate.

mGluR-2 (A-7) - sc-271655 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
mGluR-2 (A-7): sc-271655. Western blot analysis of mGluR-2 expression in LNCaP whole cell lysate.

mGluR-2 (H-130) - sc-99041 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

mGluR-2 (N-15) - sc-47135 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

mGluR-2/3 (F-25) - sc-135683 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
mGluR-2/3 (F-25): sc-135683. Western blot analysis of mGluR-2/3 expression in rat hippocampal tissue extract.

Anti-Metabotropic Glutamate Receptor 2 antibody - ab153670 from Abcam

Prices $370.00
Sizes 500 µl
Host Chicken
Clonality Polyclonal

Anti-Metabotropic Glutamate Receptor 2 antibody - ab118447 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Brain, Thalamus (formalin-fixed, paraffin-embedded) stained with ab118447 at 4 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Metabotropic Glutamate Receptor 2 antibody - ab169476 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Immunofluorescent analysis of 293 cells labeling Metabotropic Glutamate Receptor 2 with ab169476 at 1 µg/ml.

Anti-Metabotropic Glutamate Receptor 2 antibody - ab128233 from Abcam

Prices $372.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-metabotropic Glutamate Receptor 2 antibody - ab10304 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Metabotropic Glutamate Receptor 2 antibody - ab167016 from Abcam

Prices $376.00
Sizes 100 µl
Host Chicken
Clonality Polyclonal
Immunohistochemical analysis of adult mouse cochlear ganglion labeling Metabotropic Glutamate Receptor 2 with ab167016 at 1/100 dilution (green). Neuron-specific class III beta-tubulin is stained red.

Anti-Metabotropic Glutamate Receptor 2 antibody [EPR8975] - ab150387 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8975
All lanes : Anti-Metabotropic Glutamate Receptor 2 antibody [EPR8975] (ab150387) at 1/10000 dilutionLane 1 : Human hypothalamus cell lysateLane 2 : Human fetal brain cell lysateLane 3 : Human cerebellum cell lysateLane 4 : Human fetal forebrain cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-labelled goat anti-rabbit antibody at 1/2000 dilution

Anti-GRM2 / MGLUR2 Antibody (aa829-845) - LS-C16527 from LifeSpan Bioscience

Prices $560.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-GRM2 / MGLUR2 Antibody (aa853-872) - LS-C25608 from LifeSpan Bioscience

Prices $560.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-GRM2 / MGLUR2 Antibody (aa860-872) - LS-C40757 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRM2 / MGLUR2 Antibody - LS-C95993 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRM2 / MGLUR2 Antibody (aa860-872) - LS-C72501 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRM2 / MGLUR2 Antibody (C-Terminus) - LS-C122124 from LifeSpan Bioscience

Prices $815.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GRM2 / MGLUR2 Antibody (C-Terminus) - LS-C153487 from LifeSpan Bioscience

Prices $305.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM2 / MGLUR2 Antibody - LS-C308127 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-GRM2 / MGLUR2 Antibody - LS-C53446 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of a rat hippocampal (Hipp) lysate showing the specific immunolabeling of the ~100k GluR2 protein.

Anti-GRM2 / MGLUR2 Antibody (N-Terminus) IHC-plus™ - LS-A6735 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GRM2 / MGLUR2 antibody LS-A6735 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GRM2 / MGLUR2 Antibody (aa853-872) - LS-C152727 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
WB: Rat brain microsome extract probed with anti-mGluR2/3 at 0.5g/ml

Anti-GRM2 / MGLUR2 Antibody (N-Terminus) IHC-plus™ - LS-A895 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GRM2 / MGLUR2 antibody LS-A895 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GRM2 / MGLUR2 Antibody (clone 3H7) - LS-C197359 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H7
Detection limit for recombinant GST tagged GRM2 is approximately 0.3 ng/ml as a capture antibody.
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