AGO2

Gene Symbol	AGO2
Entrez Gene	27161
Alt Symbol	EIF2C2, Q10
Species	Human
Gene Type	protein-coding
Description	argonaute RISC catalytic component 2
Other Description	CTA-204B4.6|PAZ Piwi domain protein|PPD|argonaute 2|argonaute2|eIF-2C 2|eIF2C 2|eukaryotic translation initiation factor 2C, 2|hAgo2|protein argonaute-2|protein slicer
Swissprots	Q8WV58 Q96ID1 Q8TCZ5 Q9UKV8
Accessions	CAK32193 EAW92207 EAW92208 Q9UKV8 AA909234 AF121255 AAF13034 AI468419 AK096164 AK130012 AL050151 AY077717 AAL76093 BC007633 AAH07633 BC018727 AAH18727 BC054491 BC065217 BC125213 AAI25214 BC125214 BC160104 AAI60104 BT007229 AAP35893 HG501752 XM_011516964 XP_011515266 XM_011516965 XP_011515267 XM_011516966 XP_011515268 XM_011516967 XP_011515269 XM_011516968 XP_011515270 NM_001164623 NP_001158095 NM_012154 NP_036286
Function	Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t
Subcellular Location	Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

eIF2C CRISPR/Cas9 KO Plasmid (h) - sc-400813 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

eIF2C HDR Plasmid (h) - sc-400813-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

eIF2C Double Nickase Plasmid (h) - sc-400813-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

eIF2C Double Nickase Plasmid (h2) - sc-400813-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

eIF2C CRISPR Activation Plasmid (h) - sc-400813-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

eIF2C CRISPR Activation Plasmid (h2) - sc-400813-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

eIF2C Lentiviral Activation Particles (h) - sc-400813-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

eIF2C Lentiviral Activation Particles (h2) - sc-400813-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

eIF2C2 siRNA (h) - sc-44409 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

eIF2C2 shRNA Plasmid (h) - sc-44409-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

eIF2C2 shRNA (h) Lentiviral Particles - sc-44409-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ago2/eIF2C2 RNAi - H00027161-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Ago2/eIF2C2 RNAi - H00027161-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU024931 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7750 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7750 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07000 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07000

AGO2 siRNA (Human) - CRH9002 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

AGO2 - MBS8210733 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human EIF2C2 (NM_012154.3) - SHH284325 from Creative biogene Category siRNA Species Reactivities Human

Human AGO2 siRNA - orb269504 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

AGO2 shRNA Plasmid (Human) - CHH9002 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

EIF2C2 miRNA 3'UTR clone - MiUTR3H-08300 from Creative biogene Species Reactivities Human

EIF2C2 miRNA 3'UTR clone - MiUTR3H-08301 from Creative biogene Species Reactivities Human

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