Mapk14

Gene Symbol Mapk14
Entrez Gene 26416
Alt Symbol CSBP2, Crk1, Csbp1, Mxi2, PRKM14, PRKM15, p38, p38-alpha, p38MAPK, p38a, p38alpha
Species Mouse
Gene Type protein-coding
Description mitogen-activated protein kinase 14
Other Description MAP kinase 14|MAP kinase p38 alpha|MAPK 14|cytokine suppressive anti-inflammatory drug binding protein 1|mitogen activated protein kinase 14|mitogen-activated protein kinase p38 alpha|p38 MAP kinase alpha|p38 MAPK|p38 alpha|tRNA synthetase cofactor p38
Swissprots Q9QZ80 Q9JLV8 Q3UZS3 P47811 Q8C289 B2KF38 B2KF37 O08666 Q3U6R5
Accessions EDL22584 EDL22585 EDL22586 EDL22587 P47811 AF128892 AAF34818 AF195850 AAF06348 AI132714 AK089059 BAC40726 AK133684 BAE21782 AK151348 BAE30324 AK153025 BAE31659 AK177608 AK178357 AK185139 AK191704 AK192555 AK195023 AK199780 AK201673 AK205426 AK210155 AK210810 AK216421 AK218544 AK219197 BC012235 AAH12235 BC018227 BC085303 AAH85303 CX568915 D83073 BAA19741 U10871 AAA20888 X65067 CAA46200 NM_001168508 NP_001161980 NM_001168513 NP_001161985 NM_001168514 NP_001161986 NM_011951 NP_036081
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mito
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10601328}. Nucleus {ECO:0000269|PubMed:10601328}.
Tissue Specificity Macrophages, monocytes, T- and B-lymphocytes. Isoform 2 is specifically expressed in kidney and liver.
Top Pathways Adrenergic signaling in cardiomyocytes, Proteoglycans in cancer, Sphingolipid signaling pathway, Prolactin signaling pathway, Rap1 signaling pathway

Mouse-Mapk14-Antibody-N-term - AP16228a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Mapk14 Antibody (N-term) (Cat. #AP16228a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the Mapk14 antibody detected the Mapk14 protein (arrow).

Mouse Mapk14 Antibody - N-terminal region (OAAB11627) - OAAB11627 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

P38 MAPK antibody - 70R-34325 from Fitzgerald

Host Rabbit
Clonality Polyclonal

p38 MAPK antibody (Thr180) - 70R-37313 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p38 MAPK antibody (Thr179+Tyr181) - 70R-33399 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p38 MAPK antibody (Tyr322) - 70R-33397 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

P38 MAPK antibody (Tyr182) - 70R-34326 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p38 MAPK antibody (Tyr182) - 70R-37314 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p38 MAPK antibody - 70R-33400 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MAPK14 antibody - orb37616 from Biorbyt

Prices $187.00, $383.00
Sizes 80 μl (Trial size), 400 μl
Host Rabbit
Clonality Polyclonal

P38 MAPK antibody (Thr179) - 70R-34324 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p38 MAPK antibody - 70R-33398 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

P38 MAPK antibody - 70R-34327 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MAP kinase p38 alpha / MAPK14 antibody - PAB0826 from Acris Antibodies

Prices $420.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of human Mapk14 polyclonal antibody ( Cat # PAB0826 ) expression in HeLa ( A ) , HL-60 ( B ) and NIH/3T3 ( C ) whole cell lysates.

Anti-MAPK14 (C-terminal) polyclonal antibody - DPABH-28103 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

p38 antibody - 70R-51506 from Fitzgerald

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

p38 antibody - 70R-51505 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Mapk14, Polyclonal Antibody - MBS9207550 from MyBioSource

Prices $155.00, $340.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal

p38 Alpha MAPK Antibody - AHP2410 from AbD Serotec

Prices $270.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-p38/SAPK2 Antibody, clone 2F11 - MABS1754 from EMD Millipore

Prices $299.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F11

Mouse Mapk14 Antibody - 58-339 from ProSci

Prices $375.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis in Jurkat cell line lysates (35ug/lane).
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