ID2

Gene Symbol ID2
Entrez Gene 3398
Alt Symbol GIG8, ID2A, ID2H, bHLHb26
Species Human
Gene Type protein-coding
Description inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Other Description DNA-binding protein inhibitor ID-2|DNA-binding protein inhibitor ID2|cell growth-inhibiting gene 8|class B basic helix-loop-helix protein 26|helix-loop-helix protein ID2|inhibitor of differentiation 2
Swissprots Q02363
Accessions AAY14810 EAX01018 EAX01019 Q02363 AK222682 BAD96402 AK311988 BAG34927 AY634687 AAV35470 BC030639 AAH30639 BE222494 D13891 BAA02990 DQ890858 ABM81784 DQ894013 ABM84939 M97796 AAA58681 NM_002166 NP_002157
Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269|PubMed:20861012}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:20861012}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:20861012}.
Tissue Specificity Highly expressed in early fetal tissues, including those of the central nervous system.
Top Pathways TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer

Id2 (D39E8) Rabbit mAb - 3431 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D39E8
Western blot analysis of extracts from various cell lines using Id2 (D39E8) Rabbit mAb.

Id2 (E-7) - sc-398104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Id2 (E-7): sc-398104. Western blot analysis of Id2 expression in non-transfected: sc-117752 (A) and mouse Id2 transfected: sc-120939 (B) 293T whole cell lysates.

Id2 (C-20) - sc-489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Id2 (C-20): sc-489. Western blot analysis of Id2 expression in SK-N-MC whole cell lysate.

Id2 (T-15) - sc-26328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Id2 (T-15): sc-26328. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic staining of glandular cells.

Id2 (2457C5a) - sc-81298 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Id2 (2457C5a): sc-81298 Western Blot analysis of human recombinant Id2 fusion protein.

Anti-ID2 antibody - ab85990 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC image of ID2 staining in Human breast adenocarcinoma formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab85990, 1/1000, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-ID2 antibody - ab52093 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Staining of ID2 in human breast carcinoma by immunohistochemistry, using ab52093 (1/50). (Formalin fixed, Paraffin embedded section).

Anti-ID2 antibody - ab89530 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-ID2 antibody (ab89530) at 5 µg/ml + recombinant protein (the immunogen) at 0.2 µg

Anti-ID2 antibody [10C3] - ab90055 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10C3
ab90055, at a dilution of 1/50, staining ID2 in paraffin embedded Human liver tissue by Immunohistochemistry.

Anti-ID2 antibody [2457C5a] - ab53545 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2457C5a
Anti-ID2 antibody [2457C5a] (ab53545) + immunised recombinant protein

Anti-ID2 antibody, prediluted - ab52116 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab52116, staining human ID2 in breast carcinoma tissue by Immunohistochemistry, Formalin fixed Paraffin embedded tissue.

Anti-ID2 Antibody (C-Terminus) - LS-C7490 from LifeSpan Bioscience

Prices $435.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-ID2 Antibody (C-Terminus) - LS-C50475 from LifeSpan Bioscience

Prices $530.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Human breast carcinoma stained with Anti-Id2

Anti-ID2 Antibody - LS-C70710 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ID2 Antibody - LS-C70709 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-ID2 Antibody (aa60-110) - LS-C148824 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ID2 Antibody - LS-C310683 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ID2 Antibody (FITC) - LS-C317870 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ID2 Antibody (Biotin) - LS-C317871 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ID2 Antibody - LS-C317872 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ID2 Antibody (HRP) - LS-C317873 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ID2 Antibody (clone 2457C5a) - LS-C184514 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2457C5a
Western blot of immunized recombinant protein using ID2 antibody.

Anti-ID2 Antibody (C-Terminus) - LS-C102862 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ID2 antibody LS-C102862 Western blot of Fetal Thymus lysate.

Anti-ID2 Antibody - LS-C331194 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of 293T cell lysate using ID2 antibody.

Anti-ID2 Antibody - LS-C192321 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ID2 pAb in extracts from 293T cells (overexpressed ID2).
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