| Gene Symbol |
STK16
|
| Entrez Gene |
8576
|
| Alt Symbol |
KRCT, MPSK, PKL12, TSF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/threonine kinase 16
|
| Other Description |
TGF-beta-stimulated factor 1|TSF-1|hPSK|myristoylated and palmitoylated serine/threonine-protein kinase|protein kinase PKL12|protein kinase expressed in day 12 fetal liver|serine/threonine-protein kinase 16|tyrosine-protein kinase STK16
|
| Swissprots |
Q9UP78 Q5U0F8 Q9UEN3 A8K9H9 Q9BUH4 Q96KI2 O75716
|
| Accessions |
EAW70714 EAW70715 EAW70716 EAW70717 O75716 AA741170 AB020739 BAB16311 AF060798 AAC28337 AF203910 AAG23728 AJ005791 CAA06700 AJ010872 CAA09387 AK096954 AK225392 AK225526 AK292694 BAF85383 AK298471 BAG60683 AK302182 BAG63548 AK310793 AL552406 AL565684 BC002618 AAH02618 BC007381 BC019915 BC053998 AAH53998 BT019585 AAV38392 CB111662 CN268850 CN268939 CR407675 CAG28603 DB190729 EU831979 ACE87420 EU832072 ACE86734 XM_011512067 XP_011510369 XM_011512068 XP_011510370 NM_003691 NM_032768 NM_001008910 NP_001008910 NR_026909
|
| Function |
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. {ECO:0000269|PubMed:10364453}.
|
| Subcellular Location |
Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associates with Golgi and Golgi-derived vesicles. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed at very low levels. {ECO:0000269|PubMed:10364453}.
|