CD209

Gene Symbol CD209
Entrez Gene 30835
Alt Symbol CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Species Human
Gene Type protein-coding
Description CD209 molecule
Other Description C-type lectin domain family 4 member L|C-type lectin domain family 4, member L|CD209 antigen|HIV gpl20-binding protein|dendritic cell-specific ICAM-3-grabbing non-integrin 1|dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
Swissprots Q96QQ6 Q96QQ4 Q96QQ5 A8MVQ9 Q96QQ2 G5E9C4 Q96QP8 Q96QP7 Q96QQ7 A8KAM4 Q96QP9 Q96QQ1 Q96QQ0 Q9NNX6 Q96QQ8 Q2TB19 Q96QQ3
Accessions AAG13814 CAG26528 CAJ18838 EAW68991 EAW68992 EAW68993 EAW68994 EAW68995 EAW68996 EAW68997 EAW68998 EAW68999 EAW69000 EAW69001 Q9NNX6 AF290886 AAK20997 AK057212 AK293089 BAF85778 AK304190 BAG65070 AK308595 AK313585 BAG36354 AY042221 AAK91846 AY042222 AAK91847 AY042223 AAK91848 AY042224 AAK91849 AY042225 AAK91850 AY042226 AAK91851 AY042227 AAK91852 AY042228 AAK91853 AY042229 AAK91854 AY042230 AAK91855 AY042231 AAK91856 AY042232 AAK91857 AY042233 AAK91858 BC110615 AAI10616 M98457 AAF77072 XM_005272472 XP_005272529 NM_001144893 NP_001138365 NM_001144894 NP_001138366 NM_001144895 NP_001138367 NM_001144896 NP_001138368 NM_001144897 NP_001138369 NM_001144899 NP_001138371 NM_021155 NP_066978 NR_026692
Function Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.
Subcellular Location Isoform 11: Secreted {ECO:0000305}.
Tissue Specificity Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. {ECO:0000269|PubMed:11257134, ECO:0000269|PubMed:11337487}.
Top Pathways Phagosome, Measles, Tuberculosis

DC-SIGN (D7F5C) XP ® Rabbit mAb - 13193 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7F5C
Western blot analysis of extracts from human monocyte-derived dendritic cells using DC-SIGN (D7F5C) XP ® Rabbit mAb.

DC-SIGN Antibody - 9097 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MUTZ-3 cells, undifferentiated (-) or differentiated (+) into interstitial dendritic cells with Human Granulocyte Macrophage Colony Stimulating Factor (hGM-CSF) #8922 (100 ng/mL), Human Interleukin-4 (hIL-4) #8919 (100 ng/mL), and Human Tumor Necrosis Factor-α (hTNF-α) #8902 (2.5 ng/mL) for 8 d, using DC-SIGN Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

DC-SIGN (9E9A8) - sc-53967 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

DC-SIGN (C-20) - sc-11038 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DC-SIGN (C-20): sc-11038. Western blot analysis of DC-SIGN expression in HeLa (whole cell lysate.

DC-SIGN (1B10) - sc-23926 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

DC-SIGN (DC28) - sc-65740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DC-SIGN (DC28): sc-65740. Western blot analysis of human recombinant DC-SIGN (A) and DC-SIGN expression in THP-1 (B) and PMA/IL-4 treated THP-1 (C) whole cell lysates.

DC-SIGN (8C1) - sc-53580 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

DC-SIGN (MR-1) - sc-59157 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

DC-SIGN (R-17) - sc-32021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DC-SIGN (R-17): sc-32021. Western blot analysis of DC-SIGN expression in THP-1 (A), HuT 78 (B) and CCRF-CEM (C) whole cell lysates.

DC-SIGN (T-13) - sc-32022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DC-SIGN (T-13): sc-32022. Western blot analysis of human recombinant DC-SIGN fusion protein.

DC-SIGN (5D7) - sc-65892 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

DC-SIGN (DCN47.5) - sc-52660 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

DC-SIGN/DC-SIGNR (H-200) - sc-20081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DC-SIGN/DC-SIGNR (H-200): sc-20081. Western blot analysis of DC-SIGNR expression in non-transfected: sc-117752 (A) and human DC-SIGNR transfected: sc-115461 (B) 293T whole cell lysates.

DC-SIGN/DC-SIGNR (B-2) - sc-74589 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DC-SIGN/DC-SIGNR (B-2): sc-74589. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing membrane staining of hepatic sinusoids and Kupffer cells.

Anti-DC-SIGN antibody - ab5715 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab5715 at 0.5 µg /ml staining approximately 44kDa of human CD209 in Human placenta lysate by Western blot (ECL).

Anti-DC-SIGN antibody - ab5716 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab5716 at 2 µg /ml staining approximately 44kDa of human CD209 in Human placenta tissue lysate by Western blot (ECL). Lane 1 absence of blocking peptide and Lane 2 presence of blocking peptide.

Anti-DC-SIGN antibody - ab97526 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DC-SIGN antibody (ab97526) at 1/5000 dilution + HeLa whole cell lysate at 30 µg

Anti-DC-SIGN antibody - ab87375 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DC-SIGN antibody (ab87375) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 2 : THP1 (Human acute monocytic leukemia cell line) Whole Cell Lysate Lane 3 : U937 (Human leukemic monocyte lymphoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-DC-SIGN antibody [120507] - ab13487 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 120507

Anti-DC-SIGN antibody [120507] - ab90396 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 120507

Anti-DC-SIGN antibody [5D7] - ab59192 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5D7
Lane 1 : Anti-DC-SIGN antibody [5D7] (ab59192) at 0.25 µg/mlLane 2 : Anti-DC-SIGN antibody [5D7] (ab59192) at 0.5 µg/mlLane 1 : human uterus tissue lysateLane 2 : human uterus tissue lysateLysates/proteins at 15 µg per lane.SecondaryGoat-anti mouse

Anti-DC-SIGN antibody [5D7] - ab36825 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5D7
Analysis of DC-SIGN in Jurkat cells using ab36825 at 10 µg/ml.

Anti-DC-SIGN antibody [EPR5588] - ab124828 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5588
All lanes : Anti-DC-SIGN antibody [EPR5588] (ab124828) at 1/1000 dilutionLane 1 : HACAT cell lysateLane 2 : Fetal skin lysateLane 3 : Fetal artery lysateLane 4 : Human small intestine lysateLysates/proteins at 10 µg per lane.SecondaryHRP conjugated goat anti-rabbit at 1/2000 dilution

Anti-DC-SIGN antibody [h209] - ab95637 from Abcam

Prices $376.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone h209
Staining of Human monocyte derived immature dendritic cells with 0.5 µg of purified Rat IgG2a ? Isotype Control (open histogram) or ab95637 at 0.5 µg (filled histogram) followed by FITC conjugated anti-Rat IgG. Cells in the large scatter population were used for analysis.

Anti-DC-SIGN antibody [h209] (Biotin) - ab95636 from Abcam

Prices $376.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone h209
Flow cytometry staining of Human dendritic cells with 0.125 µg of Rat IgG2a ? Isotype Control Biotin (open histogram) or ab95636 (filled histogram) followed by Streptavidin PE. Cells in the large scatter population were used for analysis.
Search more