HLA-DRA

Gene Symbol HLA-DRA
Entrez Gene 3122
Alt Symbol HLA-DRA1, MLRW
Species Human
Gene Type protein-coding
Description major histocompatibility complex, class II, DR alpha
Other Description HLA class II histocompatibility antigen, DR alpha chain|MHC cell surface glycoprotein|MHC class II antigen DRA|histocompatibility antigen HLA-DR alpha
Swissprots A2BET4 Q9TP70 Q861I2 Q30160 Q6IAZ1 P01903
Accessions AAA36301 AAA36302 AAO23887 AAV74559 AAV74560 AHW47918 AHW47935 AHW47952 AHW47969 CAA23783 CAA25076 CAB06609 CAP40292 CAP40293 EAX03629 EAX03630 EAX03631 P01903 AI492718 AK297032 BAG59560 AK301134 BAG62726 AK301190 BAH13427 AK301354 BAG62899 AK304429 BAG65256 AK310161 AK313123 BAG35943 BC032350 AAH32350 BC071659 AAH71659 BG548634 BM849755 CR457013 CAG33294 DQ891595 ABM82521 DQ894789 ABM85715 J00193 AAA36272 J00194 AAA36275 J00195 J00197 K01171 AAA59785 M35979 AAA36283 M60333 AAA59787 M60334 AAA59783 V00523 CAA23782 V00528 CAA23787 NM_019111 NP_061984
Function Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa
Subcellular Location Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Top Pathways Leishmaniasis, Influenza A, HTLV-I infection, Tuberculosis, Herpes simplex infection

Human HLA DR protein fragment - ab177661 from Abcam

Category Protein
Source E. coli
Species Human
15% SDS-PAGE analysis of ab177661 (3 µg)

HLA-DRA Antibody Blocking Peptide - LS-E8472 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

HLA-DRA Antibody Blocking Peptide - LS-E8471 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

HLA-DRA-Antibody-C-term-Blocking-Peptide - BP6799b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

HLA-DRA-Antibody-N-term-Blocking-Peptide - BP6799a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant human HLA class II histocompatibility antigen, DR alpha chain protein (OPCA01152) - OPCA01152 from Aviva Systems Biology

Category Protein
Prices $220.00
Sizes 50 µg
Species Human

Human HLA-DRA protein - orb245692 from Biorbyt

Category Protein
Prices $340.00, $629.00, $1,003.00, $1,556.00
Sizes 50 μg, 200 μg, 500 μg, 1 mg
Species Human

HLA-DRA protein (His tag) - 80R-3720 from Fitzgerald

Category Protein
Prices $375.00
Sizes 100 µg
Source E.coli

Human MHCDRa Protein - abx067916 from Abbexa

Category Protein
Source E.coli
Species Human

HLA class II DR alpha / HLA-DRA (26-216, His-tag) - AR51407PU-N from Acris Antibodies

Category Protein
Prices $1,010.00
Sizes 500 µg
Source E. coli
Species Human
HLA class II DR alpha / HLA-DRA

HLA class II DR alpha / HLA-DRA (26-216, His-tag) - AR51407PU-S from Acris Antibodies

Category Protein
Prices $410.00
Sizes 100 µg
Source E. coli
Species Human
HLA class II DR alpha / HLA-DRA

HLA-DRA, 26-216aa Human, His tag, E.coli - 01-P2587 from ARP American Research Products

Category Protein
Prices $189.00, $449.00, $1,089.00
Sizes 20 µg, 50 µg, 500 µg
Species Human

Major Histocompatibility Complex Class II DR Alpha (MHCDRa), Human - 20-8400 from ARP American Research Products

Category Protein
Prices $549.00
Sizes 50 µg
Source E.coli
Species Human

HLA-DRA fusion protein - Ag11044 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

HLA-DRA fusion protein - ag11224 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant Human HLA-DRA, His-tagged - HLA-DRA-5091H from Creative Biomart

Category Protein
Source E. coli
Species Human

Recombinant Human major histocompatibility complex, class II, DR alpha, His-tagged - HLA-DRA-490H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Major Histocompatibility Complex Class II DR Alpha (MHCDRa) - RPC166Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant Major Histocompatibility Complex Class II DR Alpha (MHCDRa) - RPC166Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Recombinant human Histone deacetylase 9 - CSB-EP179094h CSB-BP179094h CSB-MP179094h from Cusabio

Category Protein
Source E.coli or Baculovirus or Mammalian cell
Species Human

Recombinant human HLA class II histocompatibility antigen, DR alpha chain protei - CSB-EP179394h CSB-BP179394h CSB-MP179394h from Cusabio

Category Protein
Source E.coli or Baculovirus or Mammalian cell
Species Human

Recombinant Human HLA class II histocompatibility antigen, DR alpha chain(HLA-DRA) - CSB-YP360793HU CSB-EP360793HU CSB-BP360793HU CSB-MP360793HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

HLA-DRA, 26-216aa, Human, His tag, E.coli - ATGP2587 from ATGen

Category Protein
Prices $105.00, $320.00, $960.00
Sizes 20 µg, 100 µg, 500 µg
Species Human
SDSPAGE
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