Gene Symbol |
Cd80
|
Entrez Gene |
12519
|
Alt Symbol |
B71, Cd28l, Ly-53, Ly53, MIC17, TSA1
|
Species |
Mouse
|
Gene Type |
protein-coding
|
Description |
CD80 antigen
|
Other Description |
B7 protein|T-lymphocyte activation antigen CD80|activation B7-1 antigen
|
Swissprots |
Q00609 Q61332
|
Accessions |
AAA37240 AAB32535 AAB32536 AAB32537 EDK97981 EDK97982 EDK97983 Q00609 AF065893 AAD25876 AF065894 AAD25877 AF065895 AAD25878 AF065896 AAD25879 AJ278965 CAC34306 AK019867 AK154329 BAE32518 AY278186 AAP57303 BC131959 AAI31960 BC145843 AAI45844 D16220 BAA03748 X60958 CAA43291 XM_006521737 XP_006521800 XM_006521738 XP_006521801 XM_006521740 XP_006521803 XM_011245811 XP_011244113 NM_009855 NP_033985
|
Function |
Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.
|
Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
Tissue Specificity |
Expressed on activated B-cells, gamma interferon stimulated monocytes and non-circulating B-cell malignancies.
|
Top Pathways |
Toll-like receptor signaling pathway, Type I diabetes mellitus, Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease
|