DDIT3

Gene Symbol DDIT3
Entrez Gene 1649
Alt Symbol CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
Species Human
Gene Type protein-coding
Description DNA-damage-inducible transcript 3
Other Description C/EBP zeta|CCAAT/enhancer-binding protein homologous protein|DDIT-3|DNA damage-inducible transcript 3 protein|c/EBP-homologous protein 10|growth arrest and DNA damage-inducible protein GADD153
Swissprots F8VS99 P35638
Accessions AAW56077 EAW97021 EAW97022 EAW97023 P35638 AA054097 AA476561 AI658803 AK316581 BAG38169 AV729744 AY461580 BC003637 AAH03637 BC064556 BC107859 BM464290 BT006691 AAP35337 BU664077 CN482428 EU831488 ACE87175 EU831575 ACE86494 S40706 AAB22646 XM_011538006 XP_011536308 NM_001195053 NP_001181982 NM_001195054 NP_001181983 NM_001195055 NP_001181984 NM_001195056 NP_001181985 NM_001195057 NP_001181986 NM_004083 NP_004074
Function Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the c
Subcellular Location Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
Top Pathways MAPK signaling pathway, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer

Human DDIT3 Gene cDNA Clone - orb142813 from Biorbyt

Prices $264.00
Sizes 10 μg
Species Human

Human-DDIT3-cDNA-Clone - DC01364 from Abgent, a WuXi AppTec company

Prices $228.15
Sizes 10 µg
Species Human
Accession BC003637

DDIT3 - MBS1268133 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC003637

Human DDIT3 ORF Clone(NM_001195053.1) - CDCL160733 from Creative Biomart

Species Human
Accession NM_001195053.1

Human DDIT3 ORF Clone(NM_001195053.1) - CDCR358447 from Creative Biomart

Species Human
Accession NM_001195053.1

Human DDIT3 ORF Clone(NM_001195053.1) - CDCR358453 from Creative Biomart

Species Human
Accession NM_001195053.1

Human DDIT3 ORF clone (NM_001195053.1) - CDCR045814 from Creative biogene

Species Human

Human DDIT3 ORF Clone (BC003637) - CDCS409302 from Creative biogene

Species Human
Accession F8VS99

Human DDIT3 ORF clone (BC003637) - CDCB158642 from Creative biogene

Species Human
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