ACKR4

Gene Symbol	ACKR4
Entrez Gene	51554
Alt Symbol	CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1
Species	Human
Gene Type	protein-coding
Description	atypical chemokine receptor 4
Other Description	C-C CKR-11|C-C chemokine receptor type 11|CC chemokine receptor-like 1|chemocentryx chemokine receptor|chemokine (C-C motif) receptor-like 1|chemokine, cc motif, receptor-like protein 1|orphan seven-transmembrane receptor, chemokine related
Swissprots	B2R9U7 Q9NPB9
Accessions	AAF44751 AAF61299 AAO65972 CBJ18620 Q9NPB9 AF110640 AAF59827 AK225927 AK304461 BAG65277 AK313923 BAG36644 BC069438 AAH69438 BC095501 AAH95501 BQ015927 DC419249 NM_016557 NP_057641 NM_178445 NP_848540
Function	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. {ECO:0000269|PubMed:10706668, ECO:0000269|PubMed:23121557, ECO:0000269|PubMed:23341447}.
Subcellular Location	Early endosome {ECO:0000269|PubMed:23341447}. Recycling endosome {ECO:0000269|PubMed:23341447}. Cell membrane {ECO:0000269|PubMed:23341447}; Multi-pass membrane protein {ECO:0000269|PubMed:23341447}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Tissue Specificity	Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine. {ECO:0000269|PubMed:10734104, ECO:0000269|PubMed:10767544, ECO:0000269|PubMed:11981810}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CCR11 full length protein - ab162591 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

ACKR2 / CCR10 / D6 Antibody Blocking Peptide - LS-E10729 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACKR2 / CCR10 / D6 Antibody Blocking Peptide - LS-E28792 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ACKR2 / CCR10 / D6 Antibody Blocking Peptide - LS-E28794 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ACKR2 / CCR10 / D6 Antibody Blocking Peptide - LS-E6802 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACKR2 / CCR10 / D6 Antibody Blocking Peptide - LS-E6801 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCR10 / GPR2 Antibody Blocking Peptide - LS-E2668 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCR10 / GPR2 Antibody Blocking Peptide - LS-E23168 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCR10 / GPR2 Antibody Blocking Peptide - LS-E28153 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCR10 / GPR2 Antibody Blocking Peptide - LS-E28154 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCR10 / GPR2 Antibody Blocking Peptide - LS-E28156 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCR10 / GPR2 Antibody Blocking Peptide - LS-E28155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human CCR10/GPR2 Protein - H00002826-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CC Chemokine Receptor D6 Protein - H00001238-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human CC Chemokine Receptor D6 Protein - H00001238-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human CC Chemokine Receptor D6 Protein - H00001238-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

CC Chemokine Receptor D6 Peptide - P0800 from Novus Biologicals Category Peptide Species Human

CC Chemokine Receptor D6 Peptide - P0799 from Novus Biologicals Category Peptide Species Human

CCBP2 Blocking Peptide - 33R-5612 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CCR11 Blocking Peptide - abx161323 from Abbexa Category Peptide Species Human

CCR11 / CCRL1 - H00051554-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

CCR11 / CCRL1 - H00051554-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CCR11 Blocking Peptide - CBP3822 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Recombinant Human CCR11 Protein - H00051554-G01 from Novus Biologicals Category Protein Prices $415.00 Sizes 2 µg Source Wheat Germ Species Human

CCR11 Blocking Peptide - abx161804 from Abbexa Category Peptide Species Human, Mouse

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