| Gene Symbol | COP1 |
|---|---|
| Entrez Gene | 817857 |
| Alt Symbol | ARABIDOPSIS THALIANA CONSTITUTIVE PHOTOMORPHOGENIC 1, ATCOP1, CONSTITUTIVE PHOTOMORPHOGENIC 1, DEETIOLATED MUTANT 340, DET340, EMB168, EMBRYO DEFECTIVE 168, FUS1, FUSCA 1, T21L14.11, T21L14_11 |
| Species | Arabidopsis thaliana |
| Gene Type | protein-coding |
| Description | E3 ubiquitin-protein ligase COP1 |
| Other Description | - |
| Swissprots | Q1JPL6 O48770 O23974 O23975 P43254 |
| Accessions | AAB91983 AEC08766 P43254 BT025337 ABF57293 NM_128855 NP_180854 |
| Function | E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. {ECO:0000269|PubMed:11967090, ECO:0000269|PubMed:12023303}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Localizes to the nucleus in darkness but is gradually relocated to the cytoplasm upon illumination. Localizes to subnuclear foci (speckle) and in dispersed nuclear localization in the dark. |
| Top Pathways | Ubiquitin mediated proteolysis, Circadian rhythm - plant |