| Gene Symbol | Rab8a |
|---|---|
| Entrez Gene | 117103 |
| Alt Symbol | Mel, Rab8 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | RAB8A, member RAS oncogene family |
| Other Description | mel transforming oncogene (derived from cell line NK14)- RAB8 homolog|ras-related protein Rab-8A |
| Swissprots | P35280 Q6DKL2 Q3B8Q4 |
| Accessions | EDL90831 EDL90832 EDL90833 EDL90834 P35280 BC071176 AAH71176 BC087584 AAH87584 BC105863 AAI05864 JN019799 AEJ31940 M83675 AAA41997 NM_053998 NP_446450 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucos |
| Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000250}. Recycling endosome membrane {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP- bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP- bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Localizes to tubular recycling endosome. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highest levels in spinal cord, heart, kidney and lung. |
| Top Pathways | Pancreatic secretion, AMPK signaling pathway |