HCK

Gene Symbol HCK
Entrez Gene 3055
Alt Symbol JTK9, p59Hck, p61Hck
Species Human
Gene Type protein-coding
Description HCK proto-oncogene, Src family tyrosine kinase
Other Description hematopoietic cell kinase|hemopoietic cell kinase|p59-HCK/p60-HCK|tyrosine-protein kinase HCK
Swissprots A8K1I1 Q9NUA4 Q96CC0 Q29RX1 P08631 Q9UMJ5 Q9H5Y5 Q5T7K1 E1P5M2 Q2VPE2 B4DQB6 Q5T7K2 Q504R5
Accessions CAA41565 EAW76392 EAW76393 EAW76394 P08631 AK026432 BAB15482 AK225819 AK289896 BAF82585 AK290928 BAF83617 AK298726 BAG60878 AK314335 AW139272 BC014435 AAH14435 BC073748 AAH73748 BC094847 AAH94847 BC108930 AAI08931 BC108931 AAI08932 BC113854 AAI13855 BC114463 AAI14464 DA465978 M16592 AAA52644 NM_001172129 NP_001165600 NM_001172130 NP_001165601 NM_001172131 NP_001165602 NM_001172132 NP_001165603 NM_001172133 NP_001165604 NM_002110 NP_002101
Function Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation
Subcellular Location Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol.
Tissue Specificity Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil. {ECO:0000269|PubMed:3453117, ECO:0000269|PubMed:8064233, ECO:0000269|PubMed:8995234}.
Top Pathways Fc gamma R-mediated phagocytosis, Chemokine signaling pathway

Human-HCK-cDNA-Clone - DC03842 from Abgent, a WuXi AppTec company

Prices $710.10
Sizes 10 µg
Species Human
Accession BC014435

HCK - MBS1266743 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC014435

Human HCK cDNA clone(NM_001172130.1) - CDFH008333 from Creative Biomart

Species Human
Accession NM_001172130.1

Human HCK cDNA clone(NM_001172129.1) - CDFH008334 from Creative Biomart

Species Human
Accession NM_001172129.1

Human HCK cDNA clone(NM_001172131.1) - CDFH008335 from Creative Biomart

Species Human
Accession NM_001172131.1

Human HCK cDNA clone(NM_001172132.1) - CDFH008336 from Creative Biomart

Species Human
Accession NM_001172132.1

Human HCK cDNA clone(NM_001172133.1) - CDFH008337 from Creative Biomart

Species Human
Accession NM_001172133.1

Human HCK ORF Clone(NM_002110.3) - CDCL165824 from Creative Biomart

Species Human
Accession NM_002110.3

Human HCK ORF Clone(NM_001172129.1) - CDCR356422 from Creative Biomart

Species Human
Accession NM_001172129.1

Human HCK ORF Clone(NM_001172130.1) - CDCR356423 from Creative Biomart

Species Human
Accession NM_001172130.1

Human HCK ORF Clone(NM_001172130.1) - CDCR356424 from Creative Biomart

Species Human
Accession NM_001172130.1

Human HCK ORF Clone(NM_001172131.1) - CDCR356425 from Creative Biomart

Species Human
Accession NM_001172131.1

Human HCK ORF Clone(NM_001172129.1) - CDCR356426 from Creative Biomart

Species Human
Accession NM_001172129.1

Human HCK ORF Clone(NM_001172131.1) - CDCR356427 from Creative Biomart

Species Human
Accession NM_001172131.1

Human HCK ORF Clone(NM_001172132.1) - CDCR356428 from Creative Biomart

Species Human
Accession NM_001172132.1

Human HCK ORF Clone(NM_001172133.1) - CDCR356429 from Creative Biomart

Species Human
Accession NM_001172133.1

Human HCK ORF Clone(NM_001172133.1) - CDCR356430 from Creative Biomart

Species Human
Accession NM_001172133.1

Human HCK ORF Clone(NM_001172132.1) - CDCR356431 from Creative Biomart

Species Human
Accession NM_001172132.1

Human HCK ORF Clone(NM_001172133.1) - CDCR356429 from Creative biogene

Species Human

Human HCK ORF clone (NM_001172129.1) - CDCL116209 from Creative biogene

Species Human

Mouse HCK ORF clone (NM_001172132.1) - CDCL116211 from Creative biogene

Species Human

Human HCK ORF clone (NM_001172131.1) - CDCL116213 from Creative biogene

Species Human

Human HCK ORF clone (NM_001172130.1) - CDCL116215 from Creative biogene

Species Human

Human HCK ORF Clone (BC014435) - CDCS408998 from Creative biogene

Species Human
Accession A8K4G3

Human HCK cDNA Clone(NM_001172130.1) - CDFH008333 from Creative biogene

Species Human
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