Egfr

Gene Symbol	Egfr
Entrez Gene	13649
Alt Symbol	9030024J15Rik, AI552599, Erbb, Errb1, Errp, Wa5, wa-2, wa2
Species	Mouse
Gene Type	protein-coding
Description	epidermal growth factor receptor
Other Description	avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|waved 2
Swissprots	Q01279
Accessions	AAG28045 AAG28046 AAG28047 AAG43241 AAL56615 EDL40666 EDL40667 Q01279 AF124513 AAD44149 AF275367 AAG24386 AF277898 AAK01081 AK004883 BAB23641 AK004911 BAB23662 AK004944 BAB23688 AK014017 AK033431 AK049452 AK087861 AK134262 AK163338 BAE37306 BC023729 AAH23729 BC030681 BQ553815 BY725722 L06864 AAA53029 U03425 AAA17899 X59698 CAA42219 X78987 CAA55587 Z12608 CAA78249 NM_007912 NP_031938 NM_207655 NP_997538
Function	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-ca
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome. Endosome membrane. Nucleus {ECO:0000250}. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (By similarity). {ECO:0000250}.
Top Pathways	Estrogen signaling pathway, PI3K-Akt signaling pathway, GnRH signaling pathway, Bladder cancer, Melanoma

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Mouse EGFR ELISA kit - orb196842 from Biorbyt Category ELISA Kit Prices $1,114.00, $1,930.00, $4,165.00 Sizes 96 assays, 192 assays, 480 assays

Epidermal growth factor receptor (EGFR), Mouse, ELISA Kit - CSB-EL007479MO from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Epidermal growth factor receptor, Egfr, Mouse, ELISA Kit - E0757m from ARP American Research Products Category ELISA Kit Prices $576.00 Sizes 96 t

Epidermal growth factor receptor, Mouse, ELISA Kit - E03E0129 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/mL,

Epidermal growth factor receptor, Mouse, ELISA Kit - E03E0329 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 5.0-100ng/ml

Custom Mouse EGFR ELISA - ELM-EGFR from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Mouse EGFR ELISA Kit - ME0136 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

EGFR, ELISA Kit - MBS2516277 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) , ELISA Kit - MBS902503 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse Epidermal growth factor receptor(EGFR) ELISA kit - CSB-EL007479MO from Cusabio Category ELISA Kit Sensitivity 0.225 ng/ml Range 0.94 ng/ml-60 ng/ml

Mouse Epidermal growth factor receptor ELISA - E03E0129 from BlueGene Biotech Category ELISA Kit Sensitivity 1.0 ng/mL

Mouse Epidermal Growth Factor Receptor (EGFR) ELISA Kit - EKU03937 from Biomatik Category ELISA Kit Prices $680.00, $3,028.00, $5,511.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 37.82 pg/mL Range 93.75-6000 pg/mL

Mouse EGFR(Epidermal Growth Factor Receptor) ELISA Kit - E-EL-M2441 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 18.75 pg/mL Range 31.25~2000 pg/mL

Mouse EGFR ELISA Kit - abx153941 from Abbexa Category ELISA Kit Range 93.75 pg/ml - 6000 pg/ml

Epidermal Growth Factor Receptor (EGFR), Mouse, ELISA Kit - DL-EGFR-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 31.2-2,000 pg/mL

Mouse EGFR(Epidermal Growth Factor Receptor) ELISA Kit - E-EL-M2441 from Elabscience Category ELISA Kit Sensitivity 18.75 pg/mL Range 31.25—2000 pg/mL

Epidermal Growth Factor Receptor, EGFR, Mouse, ELISA Kit - E-EL-M2441 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Mouse EGFR ELISA Kit - abx575493 from Abbexa Category ELISA Kit Sensitivity 14.2 pg/ml Range 31.25 pg/ml - 2000 pg/ml

Mouse EGFR ELISA - RAB1853 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Mouse Epidermal growth factor receptor (EGFR) ELISA Kit - EKC36815 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.225 ng/ml Range 0.94 ng/ml-60 ng/ml

Mouse Epidermal growth factor receptor ELISA Kit - EKE51619 from Biomatik Category ELISA Kit Prices $662.40, $2,815.20, $5,299.20 Sizes 96 t, 5x96t, 10x96t Range 78-5000 pg/ml

Mouse EGFR PicoKine™ ELISA Kit EK1433 - EK1433 from Boster Bio Category ELISA Kit Prices $369.00 Sizes 1 kit Sensitivity <15pg/ml Range 156pg/ml-10000pg/ml *This assay range is determined using common samples. For samples with low target protein concentrations, users can adjust the standard curve to extend the lower limit of assay range.

Mouse EGFR ELISA Kit - CEK1924 from Cohesion Biosciences Category ELISA Kit Prices $360.00 Sizes 96 t Sensitivity 15 pg/ml Range 156 pg/ml - 10000 pg/ml

Mouse EGFR/ErbB1 ELISA - ELM-EGFR-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Mouse EGFR ELISA Kit - orb385372 from Biorbyt Category ELISA Kit Prices $731.00 Sizes 96 test Sensitivity 15 pg/ml Range 156 pg/ml-10000 pg/ml

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