PPP6C
| Gene Symbol | PPP6C |
|---|---|
| Entrez Gene | 5537 |
| Alt Symbol | PP6, PP6C |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 6, catalytic subunit |
| Other Description | serine/threonine protein phosphatase catalytic subunit|serine/threonine-protein phosphatase 6 catalytic subunit |
| Swissprots | B7Z5K9 Q9UIC9 B2R5V6 Q5U0A2 O00743 B7Z2W9 |
| Accessions | EAW87611 EAW87612 EAW87613 O00743 AA251321 AF035158 AAD45400 AK295190 BAH12005 AK295752 BAH12178 AK299087 BAH12945 AK312332 BAG35253 AK316527 BAH14898 BC006990 AAH06990 BT019708 AAV38514 CB250498 DB037210 DC307002 DC334216 DC369815 X92972 CAA63549 XM_011518847 XP_011517149 NM_001123355 NP_001116827 NM_001123369 NP_001116841 NM_002721 NP_002712 |
| Function | Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. {ECO:0000269|PubMed:10227379, ECO:0000269|PubMed:17079228, ECO:0000269|PubMed:17568194, ECO:0000269|PubMed:9013334}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:17568194}. |
| Tissue Specificity | Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:9013334}. |
PP6 CRISPR/Cas9 KO Plasmid (h) - sc-406557 from Santa Cruz Biotechnology
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PP6 HDR Plasmid (h) - sc-406557-HDR from Santa Cruz Biotechnology
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PP6 Double Nickase Plasmid (h) - sc-406557-NIC from Santa Cruz Biotechnology
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PP6 Double Nickase Plasmid (h2) - sc-406557-NIC-2 from Santa Cruz Biotechnology
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PP6 CRISPR Activation Plasmid (h) - sc-406557-ACT from Santa Cruz Biotechnology
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PP6 CRISPR Activation Plasmid (h2) - sc-406557-ACT-2 from Santa Cruz Biotechnology
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PP6 Lentiviral Activation Particles (h) - sc-406557-LAC from Santa Cruz Biotechnology
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PP6 Lentiviral Activation Particles (h2) - sc-406557-LAC-2 from Santa Cruz Biotechnology
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PP6 siRNA (h) - sc-76205 from Santa Cruz Biotechnology
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PP6 shRNA Plasmid (h) - sc-76205-SH from Santa Cruz Biotechnology
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PP6 shRNA (h) Lentiviral Particles - sc-76205-V from Santa Cruz Biotechnology
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PPP6C RNAi - H00005537-R02 from Novus Biologicals
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MISSION® esiRNA - EHU004841 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1045 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1046 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1047 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0679 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0680 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17315 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17315 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04996 from Sigma-Aldrich
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PPP6C siRNA (Human) - CRH3716 from Cohesion Biosciences
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shRNA set against Human PPP6C(NM_002721.4) - SHR135930 from Creative biogene
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Human PPP6C siRNA - orb264218 from Biorbyt
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