SMG1

Gene Symbol	SMG1
Entrez Gene	23049
Alt Symbol	61E3.4, ATX, LIP
Species	Human
Gene Type	protein-coding
Description	SMG1 phosphatidylinositol 3-kinase-related kinase
Other Description	PI-3-kinase-related kinase SMG-1|lambda-interacting protein|lambda/iota protein kinase C-interacting protein|serine/threonine-protein kinase SMG1|smg-1 homolog, phosphatidylinositol 3-kinase-related kinase
Swissprots	Q8NFX2 Q96Q15 Q96RW3 O43305 Q96QV0 Q13284
Accessions	EAW50260 EAW50262 Q96Q15 AB007881 BAA24851 AB061371 BAB70696 AF186377 AAK58892 AF395444 AAM73708 AK025794 AK057563 AK074359 AK123332 AL833298 AW088221 AW503964 AY014957 AAK00511 BC037335 BC047629 BC156497 AAI56498 BE079340 BF333707 BU633006 CA868047 DA433527 DA854035 U32581 AAA86535 XM_005255182 XP_005255239 XM_005255183 XP_005255240 XM_005255184 XP_005255241 XM_011545769 XP_011544071 XM_011545770 XP_011544072 NM_015092 NP_055907
Function	Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR)
Subcellular Location	Nucleus {ECO:0000269|PubMed:15175154}. Cytoplasm {ECO:0000269|PubMed:15175154}.
Tissue Specificity	Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver. {ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:8524286}.
Top Pathways	mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Smg1 peptide - ab31816 from Abcam Category Peptide

Human Smg1 peptide - ab33121 from Abcam Category Peptide

Human Smg1 protein fragment - ab161516 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human SMG1 Protein - H00023049-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SMG1-Antibody-C-term-C3637-Blocking-Peptide - BP8055e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMG1 - H00023049-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMG1 - H00023049-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Serine/threonine-protein kinase SMG1(SMG1) ,partial - CSB-YP847208HU CSB-EP847208HU CSB-BP847208HU CSB-MP847208HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SMG1 Recombinant Protein Antigen - NBP1-88913PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SMG1 Recombinant Protein Antigen - NBP2-37870PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SMG1-Antibody-Central-E2281-Blocking-Peptide - BP8055f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMG1-Antibody-N-term-G14-Blocking-Peptide - BP8055d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMG1-Antibody-Center-Blocking-Peptide - BP8055c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMG1-Antibody-C-term-Blocking-Peptide - BP8055b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMG1-Antibody-N-term-Blocking-Peptide - BP8055a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMG1 Peptide, Human - M34GP14750H from Creative Peptides Category Peptide Source Synthetic. Species Human

SMG1 Recombinant Protein Antigen - NBP2-55889PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Serine/threonine-protein kinase SMG1 (SMG1), partial, Recombinant Protein - MBS1305519 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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