Trpv1

Gene Symbol Trpv1
Entrez Gene 83810
Alt Symbol TRPV1_SON, VR.5'sv, Vr1, Vr1l1
Species Rat
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 1
Other Description OTRPC1|capsaicin receptor|osm-9-like TRP channel 1|transient receptor potential cation channel subfamily V member 1|transient receptor potential vanilloid 1 supraoptic nucleus|vanilloid receptor 1|vanilloid receptor subtype 1|vanilloid receptor type 1 like protein 1|vanilloid type 1 receptor
Swissprots Q920B3 O35433 Q9JM57 Q9JM56 Q920B4 Q9JLM0
Accessions AAK83151 AAK83152 EDM05146 O35433 AB015231 BAA34942 AB040873 BAA94307 AB041029 BAA94306 AF029310 AAC53398 AF158248 AAF28389 LC008303 BAP90828 XM_008767882 XP_008766104 NM_031982 NP_114188
Function Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depre
Subcellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines.
Tissue Specificity Predominantly expressed in trigeminal and dorsal root sensory ganglia. Expressed also in hippocampus, cortex, cerebellum, olfactory bulb, mesencephalon and hindbrain. High expression in the cell bodies and dendrites of neurons in the hippocampus and in the cortex. In the brain detected also in astrocytes and pericytes. Isoform 1 and isoform 3 are expressed in brain and peripheral blood mononuclear cells. {ECO:0000269|PubMed:10644739, ECO:0000269|PubMed:15857679, ECO:0000269|PubMed:9349813}.
Top Pathways Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

Anti-VR1 antibody - ab63007 from Abcam

Host Sheep
Clonality Polyclonal

Anti-VR1 antibody - ab63104 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-VR1 antibody - ab21533 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of Vanilloid Receptor 1 in rat dorsal root ganglia frozen section .

Anti-VR1 antibody - ab45761 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody - NB100-1617 from Novus Biologicals

Prices $299.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Vanilloid R1/TRPV1 Antibody [NB100-1617] - CGRP and TRPV1 are co-expressed in most cultured trigeminal ganglion neurons. (A and C) CGRP expression in d2 trigeminal ganglion neurons plated on poly-d-lysine-coated coverslips. (B and D) The same culture shown in panel A or C costained for TRPV1 expression. Magnification bar = 200m (A and B) or 40m (C and D)

Vanilloid R1/TRPV1 Antibody - NBP1-97417 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TRPV1 Antibody [NBP1-97417] - WB analysis of TRPV1 in 1. Ntera2 cell lysate, 2. HepG2 cell lysate, 3. MCF7 cell lysate and 4. Cos7 cell lysate.

Vanilloid R1/TRPV1 Antibody - AF3066 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Vanilloid R1/TRPV1 was detected in perfusion fixed frozen sections of rat brain using Rat Vanilloid R1/TRPV1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3066) at 15 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (yellow; Catalog # NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

Vanilloid R1/TRPV1 Antibody [Alexa Fluor (R) 647] - NBP1-97417AF647 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [Biotin] - NBP1-97417B from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [DyLight 650] - NBP1-97417C from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [DyLight 488] - NBP1-97417G from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [HRP] - NBP1-97417H from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [DyLight 550] - NBP1-97417R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [Alexa Fluor (R) 405] - NBP1-97417AF405 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [Alexa Fluor (R) 700] - NBP1-97417AF700 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [Alexa Fluor (R) 488] - NBP1-97417AF488 from Novus Biologicals

Prices $329.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [FITC] - NBP1-97417F from Novus Biologicals

Prices $309.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Vanilloid R1/TRPV1 Antibody [DyLight 405] - NBP1-97417V from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

rat-TRPV1-extracellular-Antibody - AG1453 from Abgent, a WuXi AppTec company

Prices $375.00, $475.00, $575.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of TRPV1 in rat DRG: 1. Anti-Rat TRPV1 (extracellular) antibody (#AG1453), (1:200). 2. Anti-Rat TRPV1 (extracellular)  antibody, preincubated with the control peptide antigen.

TRPV1-Antibody - AG1452 from Abgent, a WuXi AppTec company

Prices $375.00, $475.00, $575.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of TRPV1 transfected HEK-293 cells: 1. Anti-TRPV1 antibody (#AG1452), (1:200). 2. Anti-TRPV1 antibody, preincubated with the control peptide antigen.
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