| Gene Symbol | STT3A |
|---|---|
| Entrez Gene | 3703 |
| Alt Symbol | ITM1, STT3-A, TMC |
| Species | Human |
| Gene Type | protein-coding |
| Description | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) |
| Other Description | B5|STT3, subunit of the oligosaccharyltransferase complex, homolog A|STT3A, cataylic subunit of the oligosaccharyltransferase complex|dolichyl-diphosphooligosaccharide protein glycotransferase|dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A|integral membrane protein 1|integral transmembrane protein 1|oligosaccharyl transferase subunit STT3A|transmembrane conserved|transmembrane protein TMC |
| Swissprots | Q8WUB4 E9PNQ1 Q86XU9 P46977 Q8TE35 B4DJ24 |
| Accessions | CAH05572 EAW67647 P46977 AK130548 AK290040 BAF82729 AK290657 BAF83346 AK295892 BAG58686 AK308902 BC020965 AAH20965 BC048348 AAH48348 BE503634 BM667548 BT007100 AAP35764 BX649102 DA577274 L38961 AAB05994 L47337 AAL77539 XM_011542807 XP_011541109 XM_011542808 XP_011541110 NM_001278503 NP_001265432 NM_001278504 NP_001265433 NM_152713 NP_689926 |
| Function | Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. {ECO:0000269|PubMed:19167329}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in brain, lung and kidney. Expressed in skin fibroblasts (at protein level). {ECO:0000269|PubMed:12887896}. |
| Top Pathways | N-Glycan biosynthesis, Protein processing in endoplasmic reticulum |